Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach

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Human biomonitoring pilot study DEMOCOPHES in Germany : Contribution to a harmonized European approach. / Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Ißleb, Sissy; Hölzer, Jürgen; Nendza, Julia; Wilhelm, Michael; Wittsiepe, Jürgen; Koch, Holger M.; Schindler, Birgit K.; Göen, Thomas; Hildebrand, Jörg; Joas, Reinhard; Joas, Anke; Casteleyn, Ludwine; Angerer, Jürgen; Castano, Argelia; Esteban, Marta; Schoeters, Greet; Den Hond, Elly; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Knudsen, Lisbeth E.; Kolossa-Gehring, Marike.

I: International Journal of Hygiene and Environmental Health, Bind 220, Nr. 4, 06.2017, s. 686-696.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Schwedler, G, Seiwert, M, Fiddicke, U, Ißleb, S, Hölzer, J, Nendza, J, Wilhelm, M, Wittsiepe, J, Koch, HM, Schindler, BK, Göen, T, Hildebrand, J, Joas, R, Joas, A, Casteleyn, L, Angerer, J, Castano, A, Esteban, M, Schoeters, G, Den Hond, E, Sepai, O, Exley, K, Bloemen, L, Knudsen, LE & Kolossa-Gehring, M 2017, 'Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach', International Journal of Hygiene and Environmental Health, bind 220, nr. 4, s. 686-696. https://doi.org/10.1016/j.ijheh.2017.01.012

APA

Schwedler, G., Seiwert, M., Fiddicke, U., Ißleb, S., Hölzer, J., Nendza, J., Wilhelm, M., Wittsiepe, J., Koch, H. M., Schindler, B. K., Göen, T., Hildebrand, J., Joas, R., Joas, A., Casteleyn, L., Angerer, J., Castano, A., Esteban, M., Schoeters, G., ... Kolossa-Gehring, M. (2017). Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach. International Journal of Hygiene and Environmental Health, 220(4), 686-696. https://doi.org/10.1016/j.ijheh.2017.01.012

Vancouver

Schwedler G, Seiwert M, Fiddicke U, Ißleb S, Hölzer J, Nendza J o.a. Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach. International Journal of Hygiene and Environmental Health. 2017 jun.;220(4):686-696. https://doi.org/10.1016/j.ijheh.2017.01.012

Author

Schwedler, Gerda ; Seiwert, Margarete ; Fiddicke, Ulrike ; Ißleb, Sissy ; Hölzer, Jürgen ; Nendza, Julia ; Wilhelm, Michael ; Wittsiepe, Jürgen ; Koch, Holger M. ; Schindler, Birgit K. ; Göen, Thomas ; Hildebrand, Jörg ; Joas, Reinhard ; Joas, Anke ; Casteleyn, Ludwine ; Angerer, Jürgen ; Castano, Argelia ; Esteban, Marta ; Schoeters, Greet ; Den Hond, Elly ; Sepai, Ovnair ; Exley, Karen ; Bloemen, Louis ; Knudsen, Lisbeth E. ; Kolossa-Gehring, Marike. / Human biomonitoring pilot study DEMOCOPHES in Germany : Contribution to a harmonized European approach. I: International Journal of Hygiene and Environmental Health. 2017 ; Bind 220, Nr. 4. s. 686-696.

Bibtex

@article{97864e8f30d04345a35ccc9dfaa0584f,
title = "Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach",
abstract = "Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries.In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6–11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study.The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV).German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS.Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern.Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe{\textquoteright}s people against environmental health risks.",
author = "Gerda Schwedler and Margarete Seiwert and Ulrike Fiddicke and Sissy I{\ss}leb and J{\"u}rgen H{\"o}lzer and Julia Nendza and Michael Wilhelm and J{\"u}rgen Wittsiepe and Koch, {Holger M.} and Schindler, {Birgit K.} and Thomas G{\"o}en and J{\"o}rg Hildebrand and Reinhard Joas and Anke Joas and Ludwine Casteleyn and J{\"u}rgen Angerer and Argelia Castano and Marta Esteban and Greet Schoeters and {Den Hond}, Elly and Ovnair Sepai and Karen Exley and Louis Bloemen and Knudsen, {Lisbeth E.} and Marike Kolossa-Gehring",
year = "2017",
month = jun,
doi = "10.1016/j.ijheh.2017.01.012",
language = "English",
volume = "220",
pages = "686--696",
journal = "International Journal of Hygiene and Environmental Health",
issn = "1438-4639",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "4",

}

RIS

TY - JOUR

T1 - Human biomonitoring pilot study DEMOCOPHES in Germany

T2 - Contribution to a harmonized European approach

AU - Schwedler, Gerda

AU - Seiwert, Margarete

AU - Fiddicke, Ulrike

AU - Ißleb, Sissy

AU - Hölzer, Jürgen

AU - Nendza, Julia

AU - Wilhelm, Michael

AU - Wittsiepe, Jürgen

AU - Koch, Holger M.

AU - Schindler, Birgit K.

AU - Göen, Thomas

AU - Hildebrand, Jörg

AU - Joas, Reinhard

AU - Joas, Anke

AU - Casteleyn, Ludwine

AU - Angerer, Jürgen

AU - Castano, Argelia

AU - Esteban, Marta

AU - Schoeters, Greet

AU - Den Hond, Elly

AU - Sepai, Ovnair

AU - Exley, Karen

AU - Bloemen, Louis

AU - Knudsen, Lisbeth E.

AU - Kolossa-Gehring, Marike

PY - 2017/6

Y1 - 2017/6

N2 - Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries.In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6–11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study.The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV).German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS.Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern.Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe’s people against environmental health risks.

AB - Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries.In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6–11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study.The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV).German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS.Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern.Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe’s people against environmental health risks.

U2 - 10.1016/j.ijheh.2017.01.012

DO - 10.1016/j.ijheh.2017.01.012

M3 - Journal article

C2 - 28254163

VL - 220

SP - 686

EP - 696

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 4

ER -

ID: 179170124