Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. / Lyngse, Frederik Plesner; Kirkeby, Carsten; Denwood, Matt; Christiansen, Lasse Engbo; Mølbak, Kåre; Holten Møller, Camilla; Skov, Robert Leo; Krause, Tyra Grove; Rasmussen, Morten; Sieber, Raphael; Johannesen, Thor Bech; Lillebæk, Troels; Fonager, Jannik; Fomsgaard, Anders; Møller, Frederik Trier; Stegger, Marc; Overvad, Maria; Spiess, Katja; Mortensen, Laust Hvas.

I: Nature Communications, Bind 13, 5760 , 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lyngse, FP, Kirkeby, C, Denwood, M, Christiansen, LE, Mølbak, K, Holten Møller, C, Skov, RL, Krause, TG, Rasmussen, M, Sieber, R, Johannesen, TB, Lillebæk, T, Fonager, J, Fomsgaard, A, Møller, FT, Stegger, M, Overvad, M, Spiess, K & Mortensen, LH 2022, 'Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark', Nature Communications, bind 13, 5760 . https://doi.org/10.1038/s41467-022-33498-0

APA

Lyngse, F. P., Kirkeby, C., Denwood, M., Christiansen, L. E., Mølbak, K., Holten Møller, C., Skov, R. L., Krause, T. G., Rasmussen, M., Sieber, R., Johannesen, T. B., Lillebæk, T., Fonager, J., Fomsgaard, A., Møller, F. T., Stegger, M., Overvad, M., Spiess, K., & Mortensen, L. H. (2022). Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. Nature Communications, 13, [5760 ]. https://doi.org/10.1038/s41467-022-33498-0

Vancouver

Lyngse FP, Kirkeby C, Denwood M, Christiansen LE, Mølbak K, Holten Møller C o.a. Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. Nature Communications. 2022;13. 5760 . https://doi.org/10.1038/s41467-022-33498-0

Author

Lyngse, Frederik Plesner ; Kirkeby, Carsten ; Denwood, Matt ; Christiansen, Lasse Engbo ; Mølbak, Kåre ; Holten Møller, Camilla ; Skov, Robert Leo ; Krause, Tyra Grove ; Rasmussen, Morten ; Sieber, Raphael ; Johannesen, Thor Bech ; Lillebæk, Troels ; Fonager, Jannik ; Fomsgaard, Anders ; Møller, Frederik Trier ; Stegger, Marc ; Overvad, Maria ; Spiess, Katja ; Mortensen, Laust Hvas. / Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. I: Nature Communications. 2022 ; Bind 13.

Bibtex

@article{ae8199ccbb2d4e2fb526083fb38af823,

title = "Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark",

abstract = "SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1–7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%–CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%–CI 1.95–2.62) and booster-vaccinated contacts (OR 2.65; 95%–CI 2.29–3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%–CI 2.15–2.84), but not for fully vaccinated (OR 0.66; 95%–CI 0.57–0.78) or booster-vaccinated primary cases (OR 0.69; 95%–CI 0.59–0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.",

author = "Lyngse, {Frederik Plesner} and Carsten Kirkeby and Matt Denwood and Christiansen, {Lasse Engbo} and K{\aa}re M{\o}lbak and {Holten M{\o}ller}, Camilla and Skov, {Robert Leo} and Krause, {Tyra Grove} and Morten Rasmussen and Raphael Sieber and Johannesen, {Thor Bech} and Troels Lilleb{\ae}k and Jannik Fonager and Anders Fomsgaard and M{\o}ller, {Frederik Trier} and Marc Stegger and Maria Overvad and Katja Spiess and Mortensen, {Laust Hvas}",

year = "2022",

doi = "10.1038/s41467-022-33498-0",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark

AU - Lyngse, Frederik Plesner

AU - Kirkeby, Carsten

AU - Denwood, Matt

AU - Christiansen, Lasse Engbo

AU - Mølbak, Kåre

AU - Holten Møller, Camilla

AU - Skov, Robert Leo

AU - Krause, Tyra Grove

AU - Rasmussen, Morten

AU - Sieber, Raphael

AU - Johannesen, Thor Bech

AU - Lillebæk, Troels

AU - Fonager, Jannik

AU - Fomsgaard, Anders

AU - Møller, Frederik Trier

AU - Stegger, Marc

AU - Overvad, Maria

AU - Spiess, Katja

AU - Mortensen, Laust Hvas

PY - 2022

Y1 - 2022

N2 - SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1–7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%–CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%–CI 1.95–2.62) and booster-vaccinated contacts (OR 2.65; 95%–CI 2.29–3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%–CI 2.15–2.84), but not for fully vaccinated (OR 0.66; 95%–CI 0.57–0.78) or booster-vaccinated primary cases (OR 0.69; 95%–CI 0.59–0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.

AB - SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1–7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%–CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%–CI 1.95–2.62) and booster-vaccinated contacts (OR 2.65; 95%–CI 2.29–3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%–CI 2.15–2.84), but not for fully vaccinated (OR 0.66; 95%–CI 0.57–0.78) or booster-vaccinated primary cases (OR 0.69; 95%–CI 0.59–0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.

U2 - 10.1038/s41467-022-33498-0

DO - 10.1038/s41467-022-33498-0

M3 - Journal article

C2 - 36180438

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5760

ER -

ID: 320490189