Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function. / Nordkap, Loa; Almstrup, Kristian; Priskorn, Lærke; Bang, Anne Kirstine; Stalder, Tobias; Petersen, Jørgen Holm; Hansen, Åse Marie; Juul, Anders; Johannsen, Trine Holm; Jørgensen, Niels.

I: Psychoneuroendocrinology, Bind 146, 105942, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nordkap, L, Almstrup, K, Priskorn, L, Bang, AK, Stalder, T, Petersen, JH, Hansen, ÅM, Juul, A, Johannsen, TH & Jørgensen, N 2022, 'Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function', Psychoneuroendocrinology, bind 146, 105942. https://doi.org/10.1016/j.psyneuen.2022.105942

APA

Nordkap, L., Almstrup, K., Priskorn, L., Bang, A. K., Stalder, T., Petersen, J. H., Hansen, Å. M., Juul, A., Johannsen, T. H., & Jørgensen, N. (2022). Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function. Psychoneuroendocrinology, 146, [105942]. https://doi.org/10.1016/j.psyneuen.2022.105942

Vancouver

Nordkap L, Almstrup K, Priskorn L, Bang AK, Stalder T, Petersen JH o.a. Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function. Psychoneuroendocrinology. 2022;146. 105942. https://doi.org/10.1016/j.psyneuen.2022.105942

Author

Nordkap, Loa ; Almstrup, Kristian ; Priskorn, Lærke ; Bang, Anne Kirstine ; Stalder, Tobias ; Petersen, Jørgen Holm ; Hansen, Åse Marie ; Juul, Anders ; Johannsen, Trine Holm ; Jørgensen, Niels. / Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function. I: Psychoneuroendocrinology. 2022 ; Bind 146.

Bibtex

@article{3ecb25b6b0ea47cd966b9e07c034552d,

title = "Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function",

abstract = "OBJECTIVE: Self-reported psychological stress has been associated with decreased semen quality. Cortisol levels in scalp hair (hair cortisol concentration, HCC) has emerged as a potential objective marker of psychological stress. Thus, we investigated if HCC was associated with markers of testicular function. Furthermore, we examined whether three common single nucleotide polymorphisms in the glucocorticoid-receptor gene (NR3C1, chromosome 5), potentially affecting receptor sensitivity, were associated with HCC and could influence the studied association between HCC and testicular function.DESIGN: Cross-sectional study.METHODS: We analysed HCC, serum-levels of reproductive hormones, semen parameters, and the three NR3C1-polymorphisms; BclI (rs41423247), Tth111I (rs10052957), and 9β (rs6198), in a population of 696 men from the general population.RESULTS: HCC was not associated with testicular function, and adjustment for the three NR3C1-polymorphisms did not alter the results. However, HCC increased significantly with the number of Tth111I minor-alleles (T) and decreased significantly with the number of 9β minor-alleles (G).CONCLUSION: Given previously shown associations between stress and semen quality, and that no association between HCC and self-reported stress was observed in the current study, we speculate that negative reproductive effects of stress may not be mediated directly by cortisol. This study demonstrates associations between HCC and glucocorticoid receptor gene variants indicating that these SNPs may influence systemic glucocorticoid levels, but the potential health effects of such alterations are yet unknown.",

author = "Loa Nordkap and Kristian Almstrup and L{\ae}rke Priskorn and Bang, {Anne Kirstine} and Tobias Stalder and Petersen, {J{\o}rgen Holm} and Hansen, {{\AA}se Marie} and Anders Juul and Johannsen, {Trine Holm} and Niels J{\o}rgensen",

year = "2022",

doi = "10.1016/j.psyneuen.2022.105942",

language = "English",

volume = "146",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function

AU - Nordkap, Loa

AU - Almstrup, Kristian

AU - Priskorn, Lærke

AU - Bang, Anne Kirstine

AU - Stalder, Tobias

AU - Petersen, Jørgen Holm

AU - Hansen, Åse Marie

AU - Juul, Anders

AU - Johannsen, Trine Holm

AU - Jørgensen, Niels

PY - 2022

Y1 - 2022

N2 - OBJECTIVE: Self-reported psychological stress has been associated with decreased semen quality. Cortisol levels in scalp hair (hair cortisol concentration, HCC) has emerged as a potential objective marker of psychological stress. Thus, we investigated if HCC was associated with markers of testicular function. Furthermore, we examined whether three common single nucleotide polymorphisms in the glucocorticoid-receptor gene (NR3C1, chromosome 5), potentially affecting receptor sensitivity, were associated with HCC and could influence the studied association between HCC and testicular function.DESIGN: Cross-sectional study.METHODS: We analysed HCC, serum-levels of reproductive hormones, semen parameters, and the three NR3C1-polymorphisms; BclI (rs41423247), Tth111I (rs10052957), and 9β (rs6198), in a population of 696 men from the general population.RESULTS: HCC was not associated with testicular function, and adjustment for the three NR3C1-polymorphisms did not alter the results. However, HCC increased significantly with the number of Tth111I minor-alleles (T) and decreased significantly with the number of 9β minor-alleles (G).CONCLUSION: Given previously shown associations between stress and semen quality, and that no association between HCC and self-reported stress was observed in the current study, we speculate that negative reproductive effects of stress may not be mediated directly by cortisol. This study demonstrates associations between HCC and glucocorticoid receptor gene variants indicating that these SNPs may influence systemic glucocorticoid levels, but the potential health effects of such alterations are yet unknown.

AB - OBJECTIVE: Self-reported psychological stress has been associated with decreased semen quality. Cortisol levels in scalp hair (hair cortisol concentration, HCC) has emerged as a potential objective marker of psychological stress. Thus, we investigated if HCC was associated with markers of testicular function. Furthermore, we examined whether three common single nucleotide polymorphisms in the glucocorticoid-receptor gene (NR3C1, chromosome 5), potentially affecting receptor sensitivity, were associated with HCC and could influence the studied association between HCC and testicular function.DESIGN: Cross-sectional study.METHODS: We analysed HCC, serum-levels of reproductive hormones, semen parameters, and the three NR3C1-polymorphisms; BclI (rs41423247), Tth111I (rs10052957), and 9β (rs6198), in a population of 696 men from the general population.RESULTS: HCC was not associated with testicular function, and adjustment for the three NR3C1-polymorphisms did not alter the results. However, HCC increased significantly with the number of Tth111I minor-alleles (T) and decreased significantly with the number of 9β minor-alleles (G).CONCLUSION: Given previously shown associations between stress and semen quality, and that no association between HCC and self-reported stress was observed in the current study, we speculate that negative reproductive effects of stress may not be mediated directly by cortisol. This study demonstrates associations between HCC and glucocorticoid receptor gene variants indicating that these SNPs may influence systemic glucocorticoid levels, but the potential health effects of such alterations are yet unknown.

U2 - 10.1016/j.psyneuen.2022.105942

DO - 10.1016/j.psyneuen.2022.105942

M3 - Journal article

C2 - 36179533

VL - 146

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

M1 - 105942

ER -

ID: 321170626