Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia

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Standard

Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. / Gunawardena, Sharmini; Karunaweera, Nadira D; Ferreira, Marcelo U; Phone-Kyaw, Myatt; Pollack, Richard J; Alifrangis, Michael; Rajakaruna, Rupika S; Konradsen, Flemming; Amerasinghe, Priyanie H; Schousboe, Mette L; Galappaththy, Gawrie N L; Abeyasinghe, Rabindra R; Hartl, Daniel L; Wirth, Dyann F.

I: American Journal of Tropical Medicine and Hygiene, Bind 82, Nr. 2, 2010, s. 235-42.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Gunawardena, S, Karunaweera, ND, Ferreira, MU, Phone-Kyaw, M, Pollack, RJ, Alifrangis, M, Rajakaruna, RS, Konradsen, F, Amerasinghe, PH, Schousboe, ML, Galappaththy, GNL, Abeyasinghe, RR, Hartl, DL & Wirth, DF 2010, 'Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia', American Journal of Tropical Medicine and Hygiene, bind 82, nr. 2, s. 235-42. https://doi.org/10.4269/ajtmh.2010.09-0588

APA

Gunawardena, S., Karunaweera, N. D., Ferreira, M. U., Phone-Kyaw, M., Pollack, R. J., Alifrangis, M., Rajakaruna, R. S., Konradsen, F., Amerasinghe, P. H., Schousboe, M. L., Galappaththy, G. N. L., Abeyasinghe, R. R., Hartl, D. L., & Wirth, D. F. (2010). Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. American Journal of Tropical Medicine and Hygiene, 82(2), 235-42. https://doi.org/10.4269/ajtmh.2010.09-0588

Vancouver

Gunawardena S, Karunaweera ND, Ferreira MU, Phone-Kyaw M, Pollack RJ, Alifrangis M o.a. Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. American Journal of Tropical Medicine and Hygiene. 2010;82(2):235-42. https://doi.org/10.4269/ajtmh.2010.09-0588

Author

Gunawardena, Sharmini ; Karunaweera, Nadira D ; Ferreira, Marcelo U ; Phone-Kyaw, Myatt ; Pollack, Richard J ; Alifrangis, Michael ; Rajakaruna, Rupika S ; Konradsen, Flemming ; Amerasinghe, Priyanie H ; Schousboe, Mette L ; Galappaththy, Gawrie N L ; Abeyasinghe, Rabindra R ; Hartl, Daniel L ; Wirth, Dyann F. / Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. I: American Journal of Tropical Medicine and Hygiene. 2010 ; Bind 82, Nr. 2. s. 235-42.

Bibtex

@article{610aee6024ae11df8ed1000ea68e967b,
title = "Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia",
abstract = "Genetic diversity and population structure of Plasmodium vivax parasites can predict the origin and spread of novel variants within a population enabling population specific malaria control measures. We analyzed the genetic diversity and population structure of 425 P. vivax isolates from Sri Lanka, Myanmar, and Ethiopia using 12 trinucleotide and tetranucleotide microsatellite markers. All three parasite populations were highly polymorphic with 3-44 alleles per locus. Approximately 65% were multiple-clone infections. Mean genetic diversity (H(E)) was 0.7517 in Ethiopia, 0.8450 in Myanmar, and 0.8610 in Sri Lanka. Significant linkage disequilibrium was maintained. Population structure showed two clusters (Asian and African) according to geography and ancestry. Strong clustering of outbreak isolates from Sri Lanka and Ethiopia was observed. Predictive power of ancestry using two-thirds of the isolates as a model identified 78.2% of isolates accurately as being African or Asian. Microsatellite analysis is a useful tool for mapping short-term outbreaks of malaria and for predicting ancestry.",
author = "Sharmini Gunawardena and Karunaweera, {Nadira D} and Ferreira, {Marcelo U} and Myatt Phone-Kyaw and Pollack, {Richard J} and Michael Alifrangis and Rajakaruna, {Rupika S} and Flemming Konradsen and Amerasinghe, {Priyanie H} and Schousboe, {Mette L} and Galappaththy, {Gawrie N L} and Abeyasinghe, {Rabindra R} and Hartl, {Daniel L} and Wirth, {Dyann F}",
year = "2010",
doi = "10.4269/ajtmh.2010.09-0588",
language = "English",
volume = "82",
pages = "235--42",
journal = "Journal. National Malaria Society",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "2",

}

RIS

TY - JOUR

T1 - Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia

AU - Gunawardena, Sharmini

AU - Karunaweera, Nadira D

AU - Ferreira, Marcelo U

AU - Phone-Kyaw, Myatt

AU - Pollack, Richard J

AU - Alifrangis, Michael

AU - Rajakaruna, Rupika S

AU - Konradsen, Flemming

AU - Amerasinghe, Priyanie H

AU - Schousboe, Mette L

AU - Galappaththy, Gawrie N L

AU - Abeyasinghe, Rabindra R

AU - Hartl, Daniel L

AU - Wirth, Dyann F

PY - 2010

Y1 - 2010

N2 - Genetic diversity and population structure of Plasmodium vivax parasites can predict the origin and spread of novel variants within a population enabling population specific malaria control measures. We analyzed the genetic diversity and population structure of 425 P. vivax isolates from Sri Lanka, Myanmar, and Ethiopia using 12 trinucleotide and tetranucleotide microsatellite markers. All three parasite populations were highly polymorphic with 3-44 alleles per locus. Approximately 65% were multiple-clone infections. Mean genetic diversity (H(E)) was 0.7517 in Ethiopia, 0.8450 in Myanmar, and 0.8610 in Sri Lanka. Significant linkage disequilibrium was maintained. Population structure showed two clusters (Asian and African) according to geography and ancestry. Strong clustering of outbreak isolates from Sri Lanka and Ethiopia was observed. Predictive power of ancestry using two-thirds of the isolates as a model identified 78.2% of isolates accurately as being African or Asian. Microsatellite analysis is a useful tool for mapping short-term outbreaks of malaria and for predicting ancestry.

AB - Genetic diversity and population structure of Plasmodium vivax parasites can predict the origin and spread of novel variants within a population enabling population specific malaria control measures. We analyzed the genetic diversity and population structure of 425 P. vivax isolates from Sri Lanka, Myanmar, and Ethiopia using 12 trinucleotide and tetranucleotide microsatellite markers. All three parasite populations were highly polymorphic with 3-44 alleles per locus. Approximately 65% were multiple-clone infections. Mean genetic diversity (H(E)) was 0.7517 in Ethiopia, 0.8450 in Myanmar, and 0.8610 in Sri Lanka. Significant linkage disequilibrium was maintained. Population structure showed two clusters (Asian and African) according to geography and ancestry. Strong clustering of outbreak isolates from Sri Lanka and Ethiopia was observed. Predictive power of ancestry using two-thirds of the isolates as a model identified 78.2% of isolates accurately as being African or Asian. Microsatellite analysis is a useful tool for mapping short-term outbreaks of malaria and for predicting ancestry.

U2 - 10.4269/ajtmh.2010.09-0588

DO - 10.4269/ajtmh.2010.09-0588

M3 - Journal article

C2 - 20133999

VL - 82

SP - 235

EP - 242

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

SN - 0002-9637

IS - 2

ER -

ID: 18294677