Extracellular matrix adaptation of tendon and skeletal muscle to exercise
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Extracellular matrix adaptation of tendon and skeletal muscle to exercise. / Kjaer, Michael; Magnusson, Peter; Krogsgaard, Michael; Boysen Møller, Jens; Olesen, Jens; Heinemeier, Katja; Hansen, Mette; Haraldsson, Bjarki; Koskinen, Satu; Esmarck, Birgitte; Langberg, Henning.
I: Journal of Anatomy, Bind 208, Nr. 4, 2006, s. 445-50.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Extracellular matrix adaptation of tendon and skeletal muscle to exercise
AU - Kjaer, Michael
AU - Magnusson, Peter
AU - Krogsgaard, Michael
AU - Boysen Møller, Jens
AU - Olesen, Jens
AU - Heinemeier, Katja
AU - Hansen, Mette
AU - Haraldsson, Bjarki
AU - Koskinen, Satu
AU - Esmarck, Birgitte
AU - Langberg, Henning
PY - 2006
Y1 - 2006
N2 - The extracellular matrix (ECM) of connective tissues enables linking to other tissues, and plays a key role in force transmission and tissue structure maintenance in tendons, ligaments, bone and muscle. ECM turnover is influenced by physical activity, and both collagen synthesis and metalloprotease activity increase with mechanical loading. This can be shown by determining propeptide and proteinase activity by microdialysis, as well as by verifying the incorporation of infused stable isotope amino acids in biopsies. Local tissue expression and release of growth factors for ECM such as IGF-1, TGF-beta and IL-6 is enhanced following exercise. For tendons, metabolic activity (e.g. detected by positron emission tomography scanning), circulatory responses (e.g. as measured by near-infrared spectroscopy and dye dilution) and collagen turnover are markedly increased after exercise. Tendon blood flow is regulated by cyclooxygenase-2 (COX-2)-mediated pathways, and glucose uptake is regulated by specific pathways in tendons that differ from those in skeletal muscle. Chronic loading in the form of physical training leads both to increased collagen turnover as well as to some degree of net collagen synthesis. These changes modify the mechanical properties and the viscoelastic characteristics of the tissue, decrease its stress-susceptibility and probably make it more load-resistant. The mechanical properties of tendon fascicles vary within a given human tendon, and even show gender differences. The latter is supported by findings of gender-related differences in the activation of collagen synthesis with exercise. These findings may provide the basis for understanding tissue overloading and injury in both tendons and skeletal muscle.
AB - The extracellular matrix (ECM) of connective tissues enables linking to other tissues, and plays a key role in force transmission and tissue structure maintenance in tendons, ligaments, bone and muscle. ECM turnover is influenced by physical activity, and both collagen synthesis and metalloprotease activity increase with mechanical loading. This can be shown by determining propeptide and proteinase activity by microdialysis, as well as by verifying the incorporation of infused stable isotope amino acids in biopsies. Local tissue expression and release of growth factors for ECM such as IGF-1, TGF-beta and IL-6 is enhanced following exercise. For tendons, metabolic activity (e.g. detected by positron emission tomography scanning), circulatory responses (e.g. as measured by near-infrared spectroscopy and dye dilution) and collagen turnover are markedly increased after exercise. Tendon blood flow is regulated by cyclooxygenase-2 (COX-2)-mediated pathways, and glucose uptake is regulated by specific pathways in tendons that differ from those in skeletal muscle. Chronic loading in the form of physical training leads both to increased collagen turnover as well as to some degree of net collagen synthesis. These changes modify the mechanical properties and the viscoelastic characteristics of the tissue, decrease its stress-susceptibility and probably make it more load-resistant. The mechanical properties of tendon fascicles vary within a given human tendon, and even show gender differences. The latter is supported by findings of gender-related differences in the activation of collagen synthesis with exercise. These findings may provide the basis for understanding tissue overloading and injury in both tendons and skeletal muscle.
KW - Bone and Bones
KW - Collagen
KW - Exercise
KW - Extracellular Matrix
KW - Female
KW - Growth Substances
KW - Humans
KW - Male
KW - Muscle Proteins
KW - Muscle, Skeletal
KW - Physical Education and Training
KW - Protein Biosynthesis
KW - Sex Factors
KW - Stress, Mechanical
KW - Tendons
U2 - 10.1111/j.1469-7580.2006.00549.x
DO - 10.1111/j.1469-7580.2006.00549.x
M3 - Journal article
C2 - 16637870
VL - 208
SP - 445
EP - 450
JO - Journal of Anatomy
JF - Journal of Anatomy
SN - 0021-8782
IS - 4
ER -
ID: 38366309