DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

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DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms. / Choi, Yoon-Jung; Cho, Jinwoo; Hong, Yun-Chul; Lee, Dong-Wook; Moon, Sungji; Park, Soo Jin; Lee, Kyung-Shin; Shin, Choong Ho; Lee, Young Ah; Kim, Bung-Nyun; Kaminsky, Zachary; Kim, Johanna Inhyang; Lim, Youn-Hee.

I: Scientific Reports, Bind 13, Nr. 1, 3501, 2023.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Choi, Y-J, Cho, J, Hong, Y-C, Lee, D-W, Moon, S, Park, SJ, Lee, K-S, Shin, CH, Lee, YA, Kim, B-N, Kaminsky, Z, Kim, JI & Lim, Y-H 2023, 'DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms', Scientific Reports, bind 13, nr. 1, 3501. https://doi.org/10.1038/s41598-023-29843-y

APA

Choi, Y-J., Cho, J., Hong, Y-C., Lee, D-W., Moon, S., Park, S. J., Lee, K-S., Shin, C. H., Lee, Y. A., Kim, B-N., Kaminsky, Z., Kim, J. I., & Lim, Y-H. (2023). DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms. Scientific Reports, 13(1), [3501]. https://doi.org/10.1038/s41598-023-29843-y

Vancouver

Choi Y-J, Cho J, Hong Y-C, Lee D-W, Moon S, Park SJ o.a. DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms. Scientific Reports. 2023;13(1). 3501. https://doi.org/10.1038/s41598-023-29843-y

Author

Choi, Yoon-Jung ; Cho, Jinwoo ; Hong, Yun-Chul ; Lee, Dong-Wook ; Moon, Sungji ; Park, Soo Jin ; Lee, Kyung-Shin ; Shin, Choong Ho ; Lee, Young Ah ; Kim, Bung-Nyun ; Kaminsky, Zachary ; Kim, Johanna Inhyang ; Lim, Youn-Hee. / DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms. I: Scientific Reports. 2023 ; Bind 13, Nr. 1.

Bibtex

@article{9d64ee258f43438bbebceafe2d63b14e,
title = "DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms",
abstract = "Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO 2) is scarce. Herein, we investigate the associations between prenatal SO 2 exposure and ADHD rating scale (ARS) at ages 4, 6 and 8 years repeatedly in a mother-child cohort (n = 329). Whole blood samples were obtained at ages 2 and 6 years, and genome-wide DNA methylation (DNAm) was analyzed for 51 children using the Illumina Infinium HumanMethylation BeadChip. We analyzed the associations between prenatal SO 2 exposure and DNAm levels at ages 2 and 6, and further investigated the association between the DNAm and ARS at ages 4, 6 and 8. Prenatal SO 2 exposure was associated with ADHD symptoms. From candidate gene analysis, DNAm levels at the 6 CpGs at age 2 were associated with prenatal SO 2 exposure levels. Of the 6 CpGs, cg07583420 (INS-IGF2) was persistently linked with ARS at ages 4, 6 and 8. Epigenome-wide analysis showed that DNAm at 6733 CpG sites were associated with prenatal SO 2 exposure, of which 58 CpGs involved in Notch signalling pathway were further associated with ARS at age 4, 6 and 8 years, persistently. DNAm at age 6 was not associated with prenatal SO 2 exposure. Changes in DNAm levels associated with prenatal SO 2 exposure during early childhood are associated with increases in ARS in later childhood. ",
keywords = "Child, Preschool, Female, Pregnancy, Humans, Child, DNA Methylation, Attention Deficit Disorder with Hyperactivity, Sulfur Dioxide, Prenatal Exposure Delayed Effects, Air Pollution",
author = "Yoon-Jung Choi and Jinwoo Cho and Yun-Chul Hong and Dong-Wook Lee and Sungji Moon and Park, {Soo Jin} and Kyung-Shin Lee and Shin, {Choong Ho} and Lee, {Young Ah} and Bung-Nyun Kim and Zachary Kaminsky and Kim, {Johanna Inhyang} and Youn-Hee Lim",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
doi = "10.1038/s41598-023-29843-y",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

AU - Choi, Yoon-Jung

AU - Cho, Jinwoo

AU - Hong, Yun-Chul

AU - Lee, Dong-Wook

AU - Moon, Sungji

AU - Park, Soo Jin

AU - Lee, Kyung-Shin

AU - Shin, Choong Ho

AU - Lee, Young Ah

AU - Kim, Bung-Nyun

AU - Kaminsky, Zachary

AU - Kim, Johanna Inhyang

AU - Lim, Youn-Hee

N1 - © 2023. The Author(s).

PY - 2023

Y1 - 2023

N2 - Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO 2) is scarce. Herein, we investigate the associations between prenatal SO 2 exposure and ADHD rating scale (ARS) at ages 4, 6 and 8 years repeatedly in a mother-child cohort (n = 329). Whole blood samples were obtained at ages 2 and 6 years, and genome-wide DNA methylation (DNAm) was analyzed for 51 children using the Illumina Infinium HumanMethylation BeadChip. We analyzed the associations between prenatal SO 2 exposure and DNAm levels at ages 2 and 6, and further investigated the association between the DNAm and ARS at ages 4, 6 and 8. Prenatal SO 2 exposure was associated with ADHD symptoms. From candidate gene analysis, DNAm levels at the 6 CpGs at age 2 were associated with prenatal SO 2 exposure levels. Of the 6 CpGs, cg07583420 (INS-IGF2) was persistently linked with ARS at ages 4, 6 and 8. Epigenome-wide analysis showed that DNAm at 6733 CpG sites were associated with prenatal SO 2 exposure, of which 58 CpGs involved in Notch signalling pathway were further associated with ARS at age 4, 6 and 8 years, persistently. DNAm at age 6 was not associated with prenatal SO 2 exposure. Changes in DNAm levels associated with prenatal SO 2 exposure during early childhood are associated with increases in ARS in later childhood.

AB - Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO 2) is scarce. Herein, we investigate the associations between prenatal SO 2 exposure and ADHD rating scale (ARS) at ages 4, 6 and 8 years repeatedly in a mother-child cohort (n = 329). Whole blood samples were obtained at ages 2 and 6 years, and genome-wide DNA methylation (DNAm) was analyzed for 51 children using the Illumina Infinium HumanMethylation BeadChip. We analyzed the associations between prenatal SO 2 exposure and DNAm levels at ages 2 and 6, and further investigated the association between the DNAm and ARS at ages 4, 6 and 8. Prenatal SO 2 exposure was associated with ADHD symptoms. From candidate gene analysis, DNAm levels at the 6 CpGs at age 2 were associated with prenatal SO 2 exposure levels. Of the 6 CpGs, cg07583420 (INS-IGF2) was persistently linked with ARS at ages 4, 6 and 8. Epigenome-wide analysis showed that DNAm at 6733 CpG sites were associated with prenatal SO 2 exposure, of which 58 CpGs involved in Notch signalling pathway were further associated with ARS at age 4, 6 and 8 years, persistently. DNAm at age 6 was not associated with prenatal SO 2 exposure. Changes in DNAm levels associated with prenatal SO 2 exposure during early childhood are associated with increases in ARS in later childhood.

KW - Child, Preschool

KW - Female

KW - Pregnancy

KW - Humans

KW - Child

KW - DNA Methylation

KW - Attention Deficit Disorder with Hyperactivity

KW - Sulfur Dioxide

KW - Prenatal Exposure Delayed Effects

KW - Air Pollution

U2 - 10.1038/s41598-023-29843-y

DO - 10.1038/s41598-023-29843-y

M3 - Journal article

C2 - 36859453

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3501

ER -

ID: 338051656