Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006

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Standard

Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. / Zhang, Jenny J; Senaratne, Tharanga N; Daniels, Rachel; Valim, Clarissa; Alifrangis, Michael; Amerasinghe, Priyanie; Konradsen, Flemming; Rajakaruna, Rupika; Wirth, Dyann F; Karunaweera, Nadira D.

I: American Journal of Tropical Medicine and Hygiene, Bind 85, Nr. 5, 01.11.2011, s. 811-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Zhang, JJ, Senaratne, TN, Daniels, R, Valim, C, Alifrangis, M, Amerasinghe, P, Konradsen, F, Rajakaruna, R, Wirth, DF & Karunaweera, ND 2011, 'Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006', American Journal of Tropical Medicine and Hygiene, bind 85, nr. 5, s. 811-4. https://doi.org/10.4269/ajtmh.2011.11-0167

APA

Zhang, J. J., Senaratne, T. N., Daniels, R., Valim, C., Alifrangis, M., Amerasinghe, P., Konradsen, F., Rajakaruna, R., Wirth, D. F., & Karunaweera, N. D. (2011). Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. American Journal of Tropical Medicine and Hygiene, 85(5), 811-4. https://doi.org/10.4269/ajtmh.2011.11-0167

Vancouver

Zhang JJ, Senaratne TN, Daniels R, Valim C, Alifrangis M, Amerasinghe P o.a. Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. American Journal of Tropical Medicine and Hygiene. 2011 nov. 1;85(5):811-4. https://doi.org/10.4269/ajtmh.2011.11-0167

Author

Zhang, Jenny J ; Senaratne, Tharanga N ; Daniels, Rachel ; Valim, Clarissa ; Alifrangis, Michael ; Amerasinghe, Priyanie ; Konradsen, Flemming ; Rajakaruna, Rupika ; Wirth, Dyann F ; Karunaweera, Nadira D. / Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. I: American Journal of Tropical Medicine and Hygiene. 2011 ; Bind 85, Nr. 5. s. 811-4.

Bibtex

@article{515984ce585c40c699f858a8d9f2a625,
title = "Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006",
abstract = "Abstract. Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.",
author = "Zhang, {Jenny J} and Senaratne, {Tharanga N} and Rachel Daniels and Clarissa Valim and Michael Alifrangis and Priyanie Amerasinghe and Flemming Konradsen and Rupika Rajakaruna and Wirth, {Dyann F} and Karunaweera, {Nadira D}",
year = "2011",
month = nov,
day = "1",
doi = "10.4269/ajtmh.2011.11-0167",
language = "English",
volume = "85",
pages = "811--4",
journal = "Journal. National Malaria Society",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "5",

}

RIS

TY - JOUR

T1 - Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006

AU - Zhang, Jenny J

AU - Senaratne, Tharanga N

AU - Daniels, Rachel

AU - Valim, Clarissa

AU - Alifrangis, Michael

AU - Amerasinghe, Priyanie

AU - Konradsen, Flemming

AU - Rajakaruna, Rupika

AU - Wirth, Dyann F

AU - Karunaweera, Nadira D

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Abstract. Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.

AB - Abstract. Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.

U2 - 10.4269/ajtmh.2011.11-0167

DO - 10.4269/ajtmh.2011.11-0167

M3 - Journal article

C2 - 22049031

VL - 85

SP - 811

EP - 814

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

SN - 0002-9637

IS - 5

ER -

ID: 35249933