Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

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Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level. / Elfving, Betina; Buttenschøn, Henriette Nørmølle; Foldager, Leslie; Poulsen, Pia H P; Andersen, Niels Johan; Grynderup, Matias Brødsgaard; Hansen, Åse M; Kolstad, Henrik A.; Kaerlev, Linda; Mikkelsen, Sigurd; Thomsen, Jane F; Børglum, Anders; Wegener, Gregers; Mors, Ole.

I: Journal of Psychiatric Research, Bind 46, Nr. 9, 09.2012, s. 1118-25.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Elfving, B, Buttenschøn, HN, Foldager, L, Poulsen, PHP, Andersen, NJ, Grynderup, MB, Hansen, ÅM, Kolstad, HA, Kaerlev, L, Mikkelsen, S, Thomsen, JF, Børglum, A, Wegener, G & Mors, O 2012, 'Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level', Journal of Psychiatric Research, bind 46, nr. 9, s. 1118-25. https://doi.org/10.1016/j.jpsychires.2012.05.003

APA

Elfving, B., Buttenschøn, H. N., Foldager, L., Poulsen, P. H. P., Andersen, N. J., Grynderup, M. B., Hansen, Å. M., Kolstad, H. A., Kaerlev, L., Mikkelsen, S., Thomsen, J. F., Børglum, A., Wegener, G., & Mors, O. (2012). Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level. Journal of Psychiatric Research, 46(9), 1118-25. https://doi.org/10.1016/j.jpsychires.2012.05.003

Vancouver

Elfving B, Buttenschøn HN, Foldager L, Poulsen PHP, Andersen NJ, Grynderup MB o.a. Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level. Journal of Psychiatric Research. 2012 sep.;46(9):1118-25. https://doi.org/10.1016/j.jpsychires.2012.05.003

Author

Elfving, Betina ; Buttenschøn, Henriette Nørmølle ; Foldager, Leslie ; Poulsen, Pia H P ; Andersen, Niels Johan ; Grynderup, Matias Brødsgaard ; Hansen, Åse M ; Kolstad, Henrik A. ; Kaerlev, Linda ; Mikkelsen, Sigurd ; Thomsen, Jane F ; Børglum, Anders ; Wegener, Gregers ; Mors, Ole. / Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level. I: Journal of Psychiatric Research. 2012 ; Bind 46, Nr. 9. s. 1118-25.

Bibtex

@article{0df6498c29ba451497150c5b4cf9b083,

title = "Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level",

abstract = "Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.",

keywords = "Adult, Aging, Analysis of Variance, Brain-Derived Neurotrophic Factor, Depression, Female, Genetic Association Studies, Genotype, Humans, Life Style, Male, Methionine, Middle Aged, Polymorphism, Single Nucleotide, Questionnaires, Regression Analysis, Sex Characteristics, Valine",

author = "Betina Elfving and Buttensch{\o}n, {Henriette N{\o}rm{\o}lle} and Leslie Foldager and Poulsen, {Pia H P} and Andersen, {Niels Johan} and Grynderup, {Matias Br{\o}dsgaard} and Hansen, {{\AA}se M} and Kolstad, {Henrik A.} and Linda Kaerlev and Sigurd Mikkelsen and Thomsen, {Jane F} and Anders B{\o}rglum and Gregers Wegener and Ole Mors",

year = "2012",

month = sep,

doi = "10.1016/j.jpsychires.2012.05.003",

language = "English",

volume = "46",

pages = "1118--25",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Pergamon Press",

number = "9",

}

RIS

TY - JOUR

T1 - Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

AU - Elfving, Betina

AU - Buttenschøn, Henriette Nørmølle

AU - Foldager, Leslie

AU - Poulsen, Pia H P

AU - Andersen, Niels Johan

AU - Grynderup, Matias Brødsgaard

AU - Hansen, Åse M

AU - Kolstad, Henrik A.

AU - Kaerlev, Linda

AU - Mikkelsen, Sigurd

AU - Thomsen, Jane F

AU - Børglum, Anders

AU - Wegener, Gregers

AU - Mors, Ole

PY - 2012/9

Y1 - 2012/9

N2 - Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.

AB - Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.

KW - Adult

KW - Aging

KW - Analysis of Variance

KW - Brain-Derived Neurotrophic Factor

KW - Depression

KW - Female

KW - Genetic Association Studies

KW - Genotype

KW - Humans

KW - Life Style

KW - Male

KW - Methionine

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Questionnaires

KW - Regression Analysis

KW - Sex Characteristics

KW - Valine

U2 - 10.1016/j.jpsychires.2012.05.003

DO - 10.1016/j.jpsychires.2012.05.003

M3 - Journal article

C2 - 22682508

VL - 46

SP - 1118

EP - 1125

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 9

ER -

ID: 44881938