Colorectal cancers detected through screening are associated with lower stages and improved survival

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Colorectal cancers detected through screening are associated with lower stages and improved survival. / Lindebjerg, Jan; Osler, Merete; Bisgaard, Claus.

I: Danish Medical Journal, Bind 61, Nr. 1, A4758, 01.2014.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lindebjerg, J, Osler, M & Bisgaard, C 2014, 'Colorectal cancers detected through screening are associated with lower stages and improved survival', Danish Medical Journal, bind 61, nr. 1, A4758. <http://www.danmedj.dk/portal/pls/portal/!PORTAL.wwpob_page.show?_docname=10495029.PDF>

APA

Lindebjerg, J., Osler, M., & Bisgaard, C. (2014). Colorectal cancers detected through screening are associated with lower stages and improved survival. Danish Medical Journal, 61(1), [A4758]. http://www.danmedj.dk/portal/pls/portal/!PORTAL.wwpob_page.show?_docname=10495029.PDF

Vancouver

Lindebjerg J, Osler M, Bisgaard C. Colorectal cancers detected through screening are associated with lower stages and improved survival. Danish Medical Journal. 2014 jan.;61(1). A4758.

Author

Lindebjerg, Jan ; Osler, Merete ; Bisgaard, Claus. / Colorectal cancers detected through screening are associated with lower stages and improved survival. I: Danish Medical Journal. 2014 ; Bind 61, Nr. 1.

Bibtex

@article{e4a0f575654c41f98dcf6f18af979775,
title = "Colorectal cancers detected through screening are associated with lower stages and improved survival",
abstract = "INTRODUCTION: Population screening for colorectal cancer (CRC) using faecal occult blood test (FOBT) will be introduced in Denmark in 2014. Prior to the implementation of the screening programme, a feasibility study was performed in 2005-2006. In this paper, occurrences of colorectal cancer in the feasibility study cohort were reviewed with respect to the effect of screening participation on stages and survival.MATERIAL AND METHODS: All cases of CRC in a feasibility study cohort diagnosed from the beginning of the study until two years after the study ended were identified. Differences in the distribution of colon cancer stages and rectal cancer groups between the various screening categories were analysed through χ(2)-tests. Survival analysis with respect to screening groups was done by Kaplan-Meier and Cox-Mantel hazard ratios, and survival was corrected for lead time.RESULTS: Colon cancers detected through screening were diagnosed at significantly lower stages than among screening non-responders. There were relatively fewer locally advanced rectal cancers among patients diagnosed through positive FOBT than among non-responders. Survival among screening cancer patients was superior to that of all other screening groups. No effect of lead time was detected. Neither stage nor survival among patients who had a negative FOBT was inferior to the unscreened Danish population.CONCLUSION: The positive effect on survival among screening cancer patients is neither outbalanced by more advanced cancers among FOBT-negative patients than among non-responders nor by risks reported for colonoscopy.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.",
keywords = "Adult, Aged, Colonoscopy, Colorectal Neoplasms, Denmark, Early Detection of Cancer, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Mass Screening, Middle Aged, Neoplasm Staging, Occult Blood, Survival Analysis",
author = "Jan Lindebjerg and Merete Osler and Claus Bisgaard",
year = "2014",
month = jan,
language = "English",
volume = "61",
journal = "Danish Medical Journal",
issn = "2245-1919",
publisher = "Almindelige Danske Laegeforening",
number = "1",

}

RIS

TY - JOUR

T1 - Colorectal cancers detected through screening are associated with lower stages and improved survival

AU - Lindebjerg, Jan

AU - Osler, Merete

AU - Bisgaard, Claus

PY - 2014/1

Y1 - 2014/1

N2 - INTRODUCTION: Population screening for colorectal cancer (CRC) using faecal occult blood test (FOBT) will be introduced in Denmark in 2014. Prior to the implementation of the screening programme, a feasibility study was performed in 2005-2006. In this paper, occurrences of colorectal cancer in the feasibility study cohort were reviewed with respect to the effect of screening participation on stages and survival.MATERIAL AND METHODS: All cases of CRC in a feasibility study cohort diagnosed from the beginning of the study until two years after the study ended were identified. Differences in the distribution of colon cancer stages and rectal cancer groups between the various screening categories were analysed through χ(2)-tests. Survival analysis with respect to screening groups was done by Kaplan-Meier and Cox-Mantel hazard ratios, and survival was corrected for lead time.RESULTS: Colon cancers detected through screening were diagnosed at significantly lower stages than among screening non-responders. There were relatively fewer locally advanced rectal cancers among patients diagnosed through positive FOBT than among non-responders. Survival among screening cancer patients was superior to that of all other screening groups. No effect of lead time was detected. Neither stage nor survival among patients who had a negative FOBT was inferior to the unscreened Danish population.CONCLUSION: The positive effect on survival among screening cancer patients is neither outbalanced by more advanced cancers among FOBT-negative patients than among non-responders nor by risks reported for colonoscopy.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Population screening for colorectal cancer (CRC) using faecal occult blood test (FOBT) will be introduced in Denmark in 2014. Prior to the implementation of the screening programme, a feasibility study was performed in 2005-2006. In this paper, occurrences of colorectal cancer in the feasibility study cohort were reviewed with respect to the effect of screening participation on stages and survival.MATERIAL AND METHODS: All cases of CRC in a feasibility study cohort diagnosed from the beginning of the study until two years after the study ended were identified. Differences in the distribution of colon cancer stages and rectal cancer groups between the various screening categories were analysed through χ(2)-tests. Survival analysis with respect to screening groups was done by Kaplan-Meier and Cox-Mantel hazard ratios, and survival was corrected for lead time.RESULTS: Colon cancers detected through screening were diagnosed at significantly lower stages than among screening non-responders. There were relatively fewer locally advanced rectal cancers among patients diagnosed through positive FOBT than among non-responders. Survival among screening cancer patients was superior to that of all other screening groups. No effect of lead time was detected. Neither stage nor survival among patients who had a negative FOBT was inferior to the unscreened Danish population.CONCLUSION: The positive effect on survival among screening cancer patients is neither outbalanced by more advanced cancers among FOBT-negative patients than among non-responders nor by risks reported for colonoscopy.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.

KW - Adult

KW - Aged

KW - Colonoscopy

KW - Colorectal Neoplasms

KW - Denmark

KW - Early Detection of Cancer

KW - Feasibility Studies

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Mass Screening

KW - Middle Aged

KW - Neoplasm Staging

KW - Occult Blood

KW - Survival Analysis

M3 - Journal article

C2 - 24393588

VL - 61

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 1

M1 - A4758

ER -

ID: 138217325