Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Jae Hyun Kim
  • Young Ah Lee
  • Lim, Youn-Hee
  • Kyunghoon Lee
  • Bung-Nyun Kim
  • Johanna Inhyang Kim
  • Yun-Chul Hong
  • Sei Won Yang
  • Junghan Song
  • Choong Ho Shin

CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.

OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.

DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.

OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.

RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).

CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
ISSN0021-972X
DOI
StatusE-pub ahead of print - 4 aug. 2020

ID: 246601480