Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study
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CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.
OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.
DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.
OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.
RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).
CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.
|Tidsskrift||The Journal of clinical endocrinology and metabolism|
|Status||E-pub ahead of print - 4 aug. 2020|