Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study
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Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men : a population-based cohort study. / Jensen, Britt W; Bjerregaard, Lise G; Ängquist, Lars; Gögenur, Ismail; Renehan, Andrew G; Osler, Merete; Sørensen, Thorkild I A; Baker, Jennifer L.
I: International Journal of Obesity, Bind 42, 01.10.2018, s. 1797-1803.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men
T2 - a population-based cohort study
AU - Jensen, Britt W
AU - Bjerregaard, Lise G
AU - Ängquist, Lars
AU - Gögenur, Ismail
AU - Renehan, Andrew G
AU - Osler, Merete
AU - Sørensen, Thorkild I A
AU - Baker, Jennifer L
PY - 2018/10/1
Y1 - 2018/10/1
N2 - BACKGROUND: Although weight gain in mid- to late adult life is associated with an increased risk of colon cancer, it is unclear if increases or losses in weight from childhood to early adulthood are differentially associated with risks of adult colon cancer.METHODS: Weight and height were measured at 7 or 13 years and in early adulthood (17-26 years) in 64,675 boys in the Copenhagen School Health Records Register and the Danish Conscription Database. Cases of colon cancer (n = 751) were identified in the Danish Cancer Registry. Boys and young men were categorized as normal weight or overweight. Associations between changes in weight and colon cancer were examined using Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: Compared with men with a normal weight at 7 years and in early adulthood, men with overweight at both ages had an increased risk of adult colon cancer (HR: 2.73, 95% CI 1.80-4.15). In contrast, men with overweight at 7 years, but not in early adulthood did not have an increased risk of colon cancer (HR: 0.73, 95% CI 0.35-1.54), nor did men with a normal weight at 7 years and overweight in early adulthood (HR: 1.28, 95% CI 0.96-1.70). Similar results were observed for weight status at age 13 years combined with early adulthood.CONCLUSIONS: Childhood overweight that persists into early adulthood is associated with an increased risk of colon cancer, whereas overweight that disappears before early adulthood or developed after childhood is not.
AB - BACKGROUND: Although weight gain in mid- to late adult life is associated with an increased risk of colon cancer, it is unclear if increases or losses in weight from childhood to early adulthood are differentially associated with risks of adult colon cancer.METHODS: Weight and height were measured at 7 or 13 years and in early adulthood (17-26 years) in 64,675 boys in the Copenhagen School Health Records Register and the Danish Conscription Database. Cases of colon cancer (n = 751) were identified in the Danish Cancer Registry. Boys and young men were categorized as normal weight or overweight. Associations between changes in weight and colon cancer were examined using Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: Compared with men with a normal weight at 7 years and in early adulthood, men with overweight at both ages had an increased risk of adult colon cancer (HR: 2.73, 95% CI 1.80-4.15). In contrast, men with overweight at 7 years, but not in early adulthood did not have an increased risk of colon cancer (HR: 0.73, 95% CI 0.35-1.54), nor did men with a normal weight at 7 years and overweight in early adulthood (HR: 1.28, 95% CI 0.96-1.70). Similar results were observed for weight status at age 13 years combined with early adulthood.CONCLUSIONS: Childhood overweight that persists into early adulthood is associated with an increased risk of colon cancer, whereas overweight that disappears before early adulthood or developed after childhood is not.
U2 - 10.1038/s41366-018-0109-y
DO - 10.1038/s41366-018-0109-y
M3 - Journal article
C2 - 29789720
VL - 42
SP - 1797
EP - 1803
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
ER -
ID: 203047091