Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Cardiovascular mortality after bilateral oophorectomy : a prospective cohort study. / Olesen, Cathrine S; Koch, Trine; Uldbjerg, Cecilie S; Gregersen, Laura S; Christensen, Jane; Dehlendorff, Christian; Priskorn, Lærke; Wilson, Louise F; Lim, Youn-Hee; Jørgensen, Jeanette T; Andersen, Zorana J; Juul, Anders; Abildgaard, Julie; Hickey, Martha; Bräuner, Elvira V.
I: Menopause , Bind 29, Nr. 1, 2022, s. 28-34.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cardiovascular mortality after bilateral oophorectomy
T2 - a prospective cohort study
AU - Olesen, Cathrine S
AU - Koch, Trine
AU - Uldbjerg, Cecilie S
AU - Gregersen, Laura S
AU - Christensen, Jane
AU - Dehlendorff, Christian
AU - Priskorn, Lærke
AU - Wilson, Louise F
AU - Lim, Youn-Hee
AU - Jørgensen, Jeanette T
AU - Andersen, Zorana J
AU - Juul, Anders
AU - Abildgaard, Julie
AU - Hickey, Martha
AU - Bräuner, Elvira V.
N1 - Copyright © 2021 by The North American Menopause Society.
PY - 2022
Y1 - 2022
N2 - OBJECTIVES: Bilateral oophorectomy permanently reduces endogenous estrogen exposure and may increase cardiovascular mortality in women. This study aimed to investigate the association between bilateral oophorectomy and cardiovascular mortality and whether this association was conditional on hysterectomy or on the use of hormone therapy at the time of study entry.METHODS: A prospective cohort study of 25,338 female nurses aged ≥ 45 years within the Danish Nurse Cohort. Nurses were enrolled in 1993 or 1999 and followed until death, emigration, or end of follow-up on December 31, 2018, whichever came first. Exposure was bilateral oophorectomy. Outcome was cardiovascular mortality. Associations were estimated using Poisson regression models with log person-years as the offset.RESULTS: A total of 2,040 (8.1%) participants underwent bilateral oophorectomy. During a mean follow-up of 21.2 (SD: 5.6) years, 772 (3.0%) nurses died from cardiovascular disease. In adjusted analyses, a 31% higher rate of cardiovascular mortality was observed after bilateral oophorectomy (aMRR 1.31; 95% CI, 0.88-1.96) compared with women who retained their ovaries. No evidence of effect modification by use of hormone therapy at baseline or by hysterectomy on the association between bilateral oophorectomy and cardiovascular mortality was observed.CONCLUSION: Bilateral oophorectomy may be associated with cardiovascular mortality in women, but the estimate was not statistically significant. Additionally, we were unable to make firm conclusions regarding the possible modifying role of hormone therapy and hysterectomy on this potential association. Additional studies are needed to replicate this work.
AB - OBJECTIVES: Bilateral oophorectomy permanently reduces endogenous estrogen exposure and may increase cardiovascular mortality in women. This study aimed to investigate the association between bilateral oophorectomy and cardiovascular mortality and whether this association was conditional on hysterectomy or on the use of hormone therapy at the time of study entry.METHODS: A prospective cohort study of 25,338 female nurses aged ≥ 45 years within the Danish Nurse Cohort. Nurses were enrolled in 1993 or 1999 and followed until death, emigration, or end of follow-up on December 31, 2018, whichever came first. Exposure was bilateral oophorectomy. Outcome was cardiovascular mortality. Associations were estimated using Poisson regression models with log person-years as the offset.RESULTS: A total of 2,040 (8.1%) participants underwent bilateral oophorectomy. During a mean follow-up of 21.2 (SD: 5.6) years, 772 (3.0%) nurses died from cardiovascular disease. In adjusted analyses, a 31% higher rate of cardiovascular mortality was observed after bilateral oophorectomy (aMRR 1.31; 95% CI, 0.88-1.96) compared with women who retained their ovaries. No evidence of effect modification by use of hormone therapy at baseline or by hysterectomy on the association between bilateral oophorectomy and cardiovascular mortality was observed.CONCLUSION: Bilateral oophorectomy may be associated with cardiovascular mortality in women, but the estimate was not statistically significant. Additionally, we were unable to make firm conclusions regarding the possible modifying role of hormone therapy and hysterectomy on this potential association. Additional studies are needed to replicate this work.
U2 - 10.1097/GME.0000000000001873
DO - 10.1097/GME.0000000000001873
M3 - Journal article
C2 - 34726195
VL - 29
SP - 28
EP - 34
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 1
ER -
ID: 284529821