Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study

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Body Mass Index Changes and Insulin Resistance at Age 4 : A Prospective Cohort Study. / Lee, Hye Jin; Lim, Youn-Hee; Hong, Yun-Chul; Shin, Choong Ho; Lee, Young Ah.

I: Frontiers in Endocrinology, Bind 13, 872591, 2022.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Lee, HJ, Lim, Y-H, Hong, Y-C, Shin, CH & Lee, YA 2022, 'Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study', Frontiers in Endocrinology, bind 13, 872591. https://doi.org/10.3389/fendo.2022.872591

APA

Lee, H. J., Lim, Y-H., Hong, Y-C., Shin, C. H., & Lee, Y. A. (2022). Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study. Frontiers in Endocrinology, 13, [872591]. https://doi.org/10.3389/fendo.2022.872591

Vancouver

Lee HJ, Lim Y-H, Hong Y-C, Shin CH, Lee YA. Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study. Frontiers in Endocrinology. 2022;13. 872591. https://doi.org/10.3389/fendo.2022.872591

Author

Lee, Hye Jin ; Lim, Youn-Hee ; Hong, Yun-Chul ; Shin, Choong Ho ; Lee, Young Ah. / Body Mass Index Changes and Insulin Resistance at Age 4 : A Prospective Cohort Study. I: Frontiers in Endocrinology. 2022 ; Bind 13.

Bibtex

@article{54bade85ee4e489eb01844580926acee,
title = "Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study",
abstract = "Objectives: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2-3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4.Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years.Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.",
keywords = "Body Mass Index, Child, Child, Preschool, Cohort Studies, Glucose, Humans, Insulin, Insulin Resistance, Prospective Studies",
author = "Lee, {Hye Jin} and Youn-Hee Lim and Yun-Chul Hong and Shin, {Choong Ho} and Lee, {Young Ah}",
note = "Copyright {\textcopyright} 2022 Lee, Lim, Hong, Shin and Lee.",
year = "2022",
doi = "10.3389/fendo.2022.872591",
language = "English",
volume = "13",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Body Mass Index Changes and Insulin Resistance at Age 4

T2 - A Prospective Cohort Study

AU - Lee, Hye Jin

AU - Lim, Youn-Hee

AU - Hong, Yun-Chul

AU - Shin, Choong Ho

AU - Lee, Young Ah

N1 - Copyright © 2022 Lee, Lim, Hong, Shin and Lee.

PY - 2022

Y1 - 2022

N2 - Objectives: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2-3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4.Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years.Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.

AB - Objectives: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2-3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4.Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years.Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.

KW - Body Mass Index

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Glucose

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Prospective Studies

U2 - 10.3389/fendo.2022.872591

DO - 10.3389/fendo.2022.872591

M3 - Journal article

C2 - 35677718

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 872591

ER -

ID: 310070650