Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

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Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study. / Leeming, Diana J.; Byrjalsen, Inger; Sand, Jannie M. B.; Bihlet, Asger R.; Lange, Peter; Thal-Singer, Ruth; Miller, Bruce E.; Karsdal, Morten A.; Vestbo, Jørgen.

I: B M C Pulmonary Medicine, Bind 17, 164, 04.12.2017, s. 1-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Leeming, DJ, Byrjalsen, I, Sand, JMB, Bihlet, AR, Lange, P, Thal-Singer, R, Miller, BE, Karsdal, MA & Vestbo, J 2017, 'Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study', B M C Pulmonary Medicine, bind 17, 164, s. 1-10. https://doi.org/10.1186/s12890-017-0505-4

APA

Leeming, D. J., Byrjalsen, I., Sand, J. M. B., Bihlet, A. R., Lange, P., Thal-Singer, R., Miller, B. E., Karsdal, M. A., & Vestbo, J. (2017). Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study. B M C Pulmonary Medicine, 17, 1-10. [164]. https://doi.org/10.1186/s12890-017-0505-4

Vancouver

Leeming DJ, Byrjalsen I, Sand JMB, Bihlet AR, Lange P, Thal-Singer R o.a. Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study. B M C Pulmonary Medicine. 2017 dec. 4;17:1-10. 164. https://doi.org/10.1186/s12890-017-0505-4

Author

Leeming, Diana J. ; Byrjalsen, Inger ; Sand, Jannie M. B. ; Bihlet, Asger R. ; Lange, Peter ; Thal-Singer, Ruth ; Miller, Bruce E. ; Karsdal, Morten A. ; Vestbo, Jørgen. / Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study. I: B M C Pulmonary Medicine. 2017 ; Bind 17. s. 1-10.

Bibtex

@article{043fa7c8c5f2492c94e49f9a8764da47,
title = "Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study",
abstract = "Background: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.Methods: One thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study (NCT00292552, trial registration in February 2006) were included. Matrix metalloproteinase (MMP)-generated fragments of collagen type I, and type VI (C1M and C6M) were assessed in month six serum samples. A random-coefficient model with both a random intercept and a random slope was used to test the ability of the markers to predict post-dose bronchodilator FEV1 (PD-FEV1) change over two years adjusting for sex, age, BMI, smoking, bronchodilator reversibility, prior exacerbations, emphysema and chronic bronchitis status at baseline.Results: Annual change of PD-FEV1 was estimated from a linear model for the two-year study period. Serum C1M and C6M were independent predictors of lung function change (p = 0.007/0.005). Smoking, bronchodilator reversibility, plasma hsCRP and emphysema were also significant predictors. The effect estimate between annual change in PD-FEV1 per one standard deviation (1SD) increase of C1M and C6M was +10.4 mL/yr. and +8.6 mL/yr. C1M, and C6M, had a significant association with baseline FEV1.Conclusion: We demonstrated that markers of tissue turnover were significantly associated with lung function change. These markers may function as prognostic biomarkers and possibly as efficacy biomarkers in clinical trials focusing on lung function change in COPD.Trial registration: NCT00292552, Retrospectively registered, trial registration in February 2006.",
keywords = "COPD, Lung function change, Prognosis, Serological marker, Extracellular matrix",
author = "Leeming, {Diana J.} and Inger Byrjalsen and Sand, {Jannie M. B.} and Bihlet, {Asger R.} and Peter Lange and Ruth Thal-Singer and Miller, {Bruce E.} and Karsdal, {Morten A.} and J{\o}rgen Vestbo",
year = "2017",
month = dec,
day = "4",
doi = "10.1186/s12890-017-0505-4",
language = "English",
volume = "17",
pages = "1--10",
journal = "B M C Pulmonary Medicine",
issn = "1471-2466",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

AU - Leeming, Diana J.

AU - Byrjalsen, Inger

AU - Sand, Jannie M. B.

AU - Bihlet, Asger R.

AU - Lange, Peter

AU - Thal-Singer, Ruth

AU - Miller, Bruce E.

AU - Karsdal, Morten A.

AU - Vestbo, Jørgen

PY - 2017/12/4

Y1 - 2017/12/4

N2 - Background: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.Methods: One thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study (NCT00292552, trial registration in February 2006) were included. Matrix metalloproteinase (MMP)-generated fragments of collagen type I, and type VI (C1M and C6M) were assessed in month six serum samples. A random-coefficient model with both a random intercept and a random slope was used to test the ability of the markers to predict post-dose bronchodilator FEV1 (PD-FEV1) change over two years adjusting for sex, age, BMI, smoking, bronchodilator reversibility, prior exacerbations, emphysema and chronic bronchitis status at baseline.Results: Annual change of PD-FEV1 was estimated from a linear model for the two-year study period. Serum C1M and C6M were independent predictors of lung function change (p = 0.007/0.005). Smoking, bronchodilator reversibility, plasma hsCRP and emphysema were also significant predictors. The effect estimate between annual change in PD-FEV1 per one standard deviation (1SD) increase of C1M and C6M was +10.4 mL/yr. and +8.6 mL/yr. C1M, and C6M, had a significant association with baseline FEV1.Conclusion: We demonstrated that markers of tissue turnover were significantly associated with lung function change. These markers may function as prognostic biomarkers and possibly as efficacy biomarkers in clinical trials focusing on lung function change in COPD.Trial registration: NCT00292552, Retrospectively registered, trial registration in February 2006.

AB - Background: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.Methods: One thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study (NCT00292552, trial registration in February 2006) were included. Matrix metalloproteinase (MMP)-generated fragments of collagen type I, and type VI (C1M and C6M) were assessed in month six serum samples. A random-coefficient model with both a random intercept and a random slope was used to test the ability of the markers to predict post-dose bronchodilator FEV1 (PD-FEV1) change over two years adjusting for sex, age, BMI, smoking, bronchodilator reversibility, prior exacerbations, emphysema and chronic bronchitis status at baseline.Results: Annual change of PD-FEV1 was estimated from a linear model for the two-year study period. Serum C1M and C6M were independent predictors of lung function change (p = 0.007/0.005). Smoking, bronchodilator reversibility, plasma hsCRP and emphysema were also significant predictors. The effect estimate between annual change in PD-FEV1 per one standard deviation (1SD) increase of C1M and C6M was +10.4 mL/yr. and +8.6 mL/yr. C1M, and C6M, had a significant association with baseline FEV1.Conclusion: We demonstrated that markers of tissue turnover were significantly associated with lung function change. These markers may function as prognostic biomarkers and possibly as efficacy biomarkers in clinical trials focusing on lung function change in COPD.Trial registration: NCT00292552, Retrospectively registered, trial registration in February 2006.

KW - COPD

KW - Lung function change

KW - Prognosis

KW - Serological marker

KW - Extracellular matrix

U2 - 10.1186/s12890-017-0505-4

DO - 10.1186/s12890-017-0505-4

M3 - Journal article

C2 - 29202744

VL - 17

SP - 1

EP - 10

JO - B M C Pulmonary Medicine

JF - B M C Pulmonary Medicine

SN - 1471-2466

M1 - 164

ER -

ID: 188197618