Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals
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Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals. / Knorr, Ulla; Blom, Rasmus Ahrens; Simonsen, Anja Hviid; Poulsen, Henrik Enghusen; Akhoj, Morten; Forman, Julie; Hasselbalch, Steen Gregers; Kessing, Lars Vedel.
I: Nordic Journal of Psychiatry, Bind 75, Nr. 7, 2021, s. 532-537 .Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals
AU - Knorr, Ulla
AU - Blom, Rasmus Ahrens
AU - Simonsen, Anja Hviid
AU - Poulsen, Henrik Enghusen
AU - Akhoj, Morten
AU - Forman, Julie
AU - Hasselbalch, Steen Gregers
AU - Kessing, Lars Vedel
PY - 2021
Y1 - 2021
N2 - ObjectivePatients with neurodegenerative disorders, schizophrenia, and bipolar disorder present with increased oxidative stress markers. Not only is oxidative stress associated with development of disease, but also with increased disease progression and mortality. Oxidative stress reflects an increase in pro-oxidants, which subsequently leads to oxidative modifications of cellular components, such as RNA and DNA. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2 '-deoxyguanosine (8-oxodG) is the valid marker of whole-body RNA and DNA damage, respectively. Recently, cerebrospinal fluid (CSF) oxidative stress markers of RNA damage (8-oxoGuo) have showed both state and trait dependence in patients with bipolar disorder. However, the relation to subjective measures of stress and quality of life (QoL) is unknown.Materials and methodsThis prospective, longitudinal 1-year follow-up case-control study investigated the association between the oxidative stress markers, 8-oxoGuo and 8-oxodG and, perceived stress and QoL in patients with bipolar disorder (n = 86, 51% female) and gender-and-age-matched healthy control (HC) individuals (n = 44, 44% female). Oxidative stress markers obtained in CSF and urine were analysed using ultra-performance liquid chromatography-tandem mass spectrometry. The subjective perception of stress was assessed using the Perceived Stress Scale. Subjective evaluation of QoL was assessed using the World Health Organization Quality of Life questionnaire.Results and conclusionWe found that markers of oxidative stress in CSF and urine were not associated with perceived stress and QoL quality in patients with bipolar disorder. However, a putative association between urinary 8-oxoGuo oxidative stress marker for RNA damage and perceived stress in HC encourages further investigations.
AB - ObjectivePatients with neurodegenerative disorders, schizophrenia, and bipolar disorder present with increased oxidative stress markers. Not only is oxidative stress associated with development of disease, but also with increased disease progression and mortality. Oxidative stress reflects an increase in pro-oxidants, which subsequently leads to oxidative modifications of cellular components, such as RNA and DNA. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2 '-deoxyguanosine (8-oxodG) is the valid marker of whole-body RNA and DNA damage, respectively. Recently, cerebrospinal fluid (CSF) oxidative stress markers of RNA damage (8-oxoGuo) have showed both state and trait dependence in patients with bipolar disorder. However, the relation to subjective measures of stress and quality of life (QoL) is unknown.Materials and methodsThis prospective, longitudinal 1-year follow-up case-control study investigated the association between the oxidative stress markers, 8-oxoGuo and 8-oxodG and, perceived stress and QoL in patients with bipolar disorder (n = 86, 51% female) and gender-and-age-matched healthy control (HC) individuals (n = 44, 44% female). Oxidative stress markers obtained in CSF and urine were analysed using ultra-performance liquid chromatography-tandem mass spectrometry. The subjective perception of stress was assessed using the Perceived Stress Scale. Subjective evaluation of QoL was assessed using the World Health Organization Quality of Life questionnaire.Results and conclusionWe found that markers of oxidative stress in CSF and urine were not associated with perceived stress and QoL quality in patients with bipolar disorder. However, a putative association between urinary 8-oxoGuo oxidative stress marker for RNA damage and perceived stress in HC encourages further investigations.
KW - Bipolar disorder
KW - oxidative stress
KW - perceived stress
KW - cerebrospinal fluid
KW - case-control
U2 - 10.1080/08039488.2021.1901987
DO - 10.1080/08039488.2021.1901987
M3 - Journal article
C2 - 33781161
VL - 75
SP - 532
EP - 537
JO - Nordisk Psykiatrisk Tidsskrift
JF - Nordisk Psykiatrisk Tidsskrift
SN - 0803-9496
IS - 7
ER -
ID: 259425316