Association of phthalate exposure with autistic traits in children

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Association of phthalate exposure with autistic traits in children. / Kim, Johanna Inhyang; Lee, Jung; Lee, Kyung-Shin; Lee, Young Ah; Shin, Choong Ho; Hong, Yun-Chul; Kim, Bung-Nyun; Lim, Youn-Hee.

I: Environment International, Bind 157, 106775, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kim, JI, Lee, J, Lee, K-S, Lee, YA, Shin, CH, Hong, Y-C, Kim, B-N & Lim, Y-H 2021, 'Association of phthalate exposure with autistic traits in children', Environment International, bind 157, 106775. https://doi.org/10.1016/j.envint.2021.106775

APA

Kim, J. I., Lee, J., Lee, K-S., Lee, Y. A., Shin, C. H., Hong, Y-C., Kim, B-N., & Lim, Y-H. (2021). Association of phthalate exposure with autistic traits in children. Environment International, 157, [106775]. https://doi.org/10.1016/j.envint.2021.106775

Vancouver

Kim JI, Lee J, Lee K-S, Lee YA, Shin CH, Hong Y-C o.a. Association of phthalate exposure with autistic traits in children. Environment International. 2021;157. 106775. https://doi.org/10.1016/j.envint.2021.106775

Author

Kim, Johanna Inhyang ; Lee, Jung ; Lee, Kyung-Shin ; Lee, Young Ah ; Shin, Choong Ho ; Hong, Yun-Chul ; Kim, Bung-Nyun ; Lim, Youn-Hee. / Association of phthalate exposure with autistic traits in children. I: Environment International. 2021 ; Bind 157.

Bibtex

@article{7a622440479c47329d0426f8097fc4a4,

title = "Association of phthalate exposure with autistic traits in children",

abstract = "BACKGROUND: Phthalates are synthetic chemicals with endocrine-disrupting properties. They are reportedly associated with various neurotoxic outcomes. Studies on exposure to phthalates and children's autistic traits have shown inconsistent results with respect to sex and susceptible time periods. We investigated the association of phthalate exposure during the prenatal period and childhood with autistic traits over time using a birth cohort in South Korea.METHODS: Five phthalate metabolites were measured during mid-term pregnancy and children's follow-up at ages of 4, 6, and 8 years among a total of 547 mother-child pairs. The social communication questionnaire (SCQ) was used to assess autistic traits of children at each time point. The relationship between phthalate metabolites and SCQ scores were analyzed by exposure windows and sex.RESULTS: A 2.7 fold increase in di-(2-ethylhexyl) phthalate metabolite levels, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) during pregnancy was associated with increased SCQ scores at 4 years by 8.5% (95% confidence intervals [CI]: 1.9%, 15.5%) and 7.4% (95% CI: 0.3%, 15.0%), respectively, but not at the age of 6 or 8 years. Moreover, MEHHP levels at ages of 4 and 8 years were associated with increased SCQ scores at 8 years by 9.9% (95% CI: 1.8%, 18.6%) and 9.6% (95% CI: 1.3%, 18.6%), respectively. Boys showed stronger associations between phthalate exposure and SCQ scores than girls.CONCLUSION: The study suggested different susceptible time windows of phthalate exposure: exposure during pregnancy is associated with autistic traits in young children, whereas exposure during early childhood years leads to autistic traits in school-aged children, particularly boys.",

author = "Kim, {Johanna Inhyang} and Jung Lee and Kyung-Shin Lee and Lee, {Young Ah} and Shin, {Choong Ho} and Yun-Chul Hong and Bung-Nyun Kim and Youn-Hee Lim",

year = "2021",

doi = "10.1016/j.envint.2021.106775",

language = "English",

volume = "157",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Association of phthalate exposure with autistic traits in children

AU - Kim, Johanna Inhyang

AU - Lee, Jung

AU - Lee, Kyung-Shin

AU - Lee, Young Ah

AU - Shin, Choong Ho

AU - Hong, Yun-Chul

AU - Kim, Bung-Nyun

AU - Lim, Youn-Hee

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Phthalates are synthetic chemicals with endocrine-disrupting properties. They are reportedly associated with various neurotoxic outcomes. Studies on exposure to phthalates and children's autistic traits have shown inconsistent results with respect to sex and susceptible time periods. We investigated the association of phthalate exposure during the prenatal period and childhood with autistic traits over time using a birth cohort in South Korea.METHODS: Five phthalate metabolites were measured during mid-term pregnancy and children's follow-up at ages of 4, 6, and 8 years among a total of 547 mother-child pairs. The social communication questionnaire (SCQ) was used to assess autistic traits of children at each time point. The relationship between phthalate metabolites and SCQ scores were analyzed by exposure windows and sex.RESULTS: A 2.7 fold increase in di-(2-ethylhexyl) phthalate metabolite levels, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) during pregnancy was associated with increased SCQ scores at 4 years by 8.5% (95% confidence intervals [CI]: 1.9%, 15.5%) and 7.4% (95% CI: 0.3%, 15.0%), respectively, but not at the age of 6 or 8 years. Moreover, MEHHP levels at ages of 4 and 8 years were associated with increased SCQ scores at 8 years by 9.9% (95% CI: 1.8%, 18.6%) and 9.6% (95% CI: 1.3%, 18.6%), respectively. Boys showed stronger associations between phthalate exposure and SCQ scores than girls.CONCLUSION: The study suggested different susceptible time windows of phthalate exposure: exposure during pregnancy is associated with autistic traits in young children, whereas exposure during early childhood years leads to autistic traits in school-aged children, particularly boys.

AB - BACKGROUND: Phthalates are synthetic chemicals with endocrine-disrupting properties. They are reportedly associated with various neurotoxic outcomes. Studies on exposure to phthalates and children's autistic traits have shown inconsistent results with respect to sex and susceptible time periods. We investigated the association of phthalate exposure during the prenatal period and childhood with autistic traits over time using a birth cohort in South Korea.METHODS: Five phthalate metabolites were measured during mid-term pregnancy and children's follow-up at ages of 4, 6, and 8 years among a total of 547 mother-child pairs. The social communication questionnaire (SCQ) was used to assess autistic traits of children at each time point. The relationship between phthalate metabolites and SCQ scores were analyzed by exposure windows and sex.RESULTS: A 2.7 fold increase in di-(2-ethylhexyl) phthalate metabolite levels, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) during pregnancy was associated with increased SCQ scores at 4 years by 8.5% (95% confidence intervals [CI]: 1.9%, 15.5%) and 7.4% (95% CI: 0.3%, 15.0%), respectively, but not at the age of 6 or 8 years. Moreover, MEHHP levels at ages of 4 and 8 years were associated with increased SCQ scores at 8 years by 9.9% (95% CI: 1.8%, 18.6%) and 9.6% (95% CI: 1.3%, 18.6%), respectively. Boys showed stronger associations between phthalate exposure and SCQ scores than girls.CONCLUSION: The study suggested different susceptible time windows of phthalate exposure: exposure during pregnancy is associated with autistic traits in young children, whereas exposure during early childhood years leads to autistic traits in school-aged children, particularly boys.

U2 - 10.1016/j.envint.2021.106775

DO - 10.1016/j.envint.2021.106775

M3 - Journal article

C2 - 34314979

VL - 157

JO - Environment international

JF - Environment international

SN - 0160-4120

M1 - 106775

ER -

ID: 275243485