Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults
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Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults. / Bendix, Laila; Thinggaard, Mikael; Kimura, Masayuki; Aviv, Abraham; Christensen, Kaare; Osler, Merete; Avlund, Kirsten.
I: Journal of Aging Research, Bind 2014, 403253, 2014, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults
AU - Bendix, Laila
AU - Thinggaard, Mikael
AU - Kimura, Masayuki
AU - Aviv, Abraham
AU - Christensen, Kaare
AU - Osler, Merete
AU - Avlund, Kirsten
PY - 2014
Y1 - 2014
N2 - Introduction. Fatigue is often present in older adults with no identified underlying cause. The accruing burden of oxidative stress and inflammation might be underlying factors of fatigue. We therefore hypothesized that leukocyte telomere length (LTL) is relatively short in older adults who experience fatigue. Materials and Methods. We assessed 439 older nondisabled Danish twins. LTL was measured using Southern blots of terminal restriction fragments. Fatigue was measured by the Mob-T Scale based on questions on whether the respondents felt fatigued after performing six mobility items. Results. LTL was significantly associated with fatigue (P = 0.023), showing an increase of 0.038 kb/fatigue score unit. Aging-related diseases and mental health did not explain the association, while lifestyle factors slightly attenuated the estimates. Conclusion. Our results support an association between LTL and fatigue. Further studies are required to confirm this finding and the link of LTL with oxidative stress/inflammation over the life course.
AB - Introduction. Fatigue is often present in older adults with no identified underlying cause. The accruing burden of oxidative stress and inflammation might be underlying factors of fatigue. We therefore hypothesized that leukocyte telomere length (LTL) is relatively short in older adults who experience fatigue. Materials and Methods. We assessed 439 older nondisabled Danish twins. LTL was measured using Southern blots of terminal restriction fragments. Fatigue was measured by the Mob-T Scale based on questions on whether the respondents felt fatigued after performing six mobility items. Results. LTL was significantly associated with fatigue (P = 0.023), showing an increase of 0.038 kb/fatigue score unit. Aging-related diseases and mental health did not explain the association, while lifestyle factors slightly attenuated the estimates. Conclusion. Our results support an association between LTL and fatigue. Further studies are required to confirm this finding and the link of LTL with oxidative stress/inflammation over the life course.
U2 - 10.1155/2014/403253
DO - 10.1155/2014/403253
M3 - Journal article
C2 - 24693429
VL - 2014
SP - 1
EP - 8
JO - Journal of Aging Research
JF - Journal of Aging Research
SN - 2090-2204
M1 - 403253
ER -
ID: 138412565