Association between SARS-CoV-2 infection and self-harm: Danish nationwide register-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Association between SARS-CoV-2 infection and self-harm : Danish nationwide register-based cohort study. / Erlangsen, Annette; Qin, Ping; Madsen, Trine; Hawton, Keith; Osler, Merete; Hjorthøj, Carsten; Benros, Michael E; Ethelberg, Steen; Mølbak, Kåre; Laursen, Thomas Munk; Nordentoft, Merete; Nilsson, Sandra Feodor.

I: The British journal of psychiatry : the journal of mental science, Bind 222, Nr. 4, 2023, s. 167–174.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Erlangsen, A, Qin, P, Madsen, T, Hawton, K, Osler, M, Hjorthøj, C, Benros, ME, Ethelberg, S, Mølbak, K, Laursen, TM, Nordentoft, M & Nilsson, SF 2023, 'Association between SARS-CoV-2 infection and self-harm: Danish nationwide register-based cohort study', The British journal of psychiatry : the journal of mental science, bind 222, nr. 4, s. 167–174. https://doi.org/10.1192/bjp.2022.194

APA

Erlangsen, A., Qin, P., Madsen, T., Hawton, K., Osler, M., Hjorthøj, C., Benros, M. E., Ethelberg, S., Mølbak, K., Laursen, T. M., Nordentoft, M., & Nilsson, S. F. (2023). Association between SARS-CoV-2 infection and self-harm: Danish nationwide register-based cohort study. The British journal of psychiatry : the journal of mental science, 222(4), 167–174. https://doi.org/10.1192/bjp.2022.194

Vancouver

Erlangsen A, Qin P, Madsen T, Hawton K, Osler M, Hjorthøj C o.a. Association between SARS-CoV-2 infection and self-harm: Danish nationwide register-based cohort study. The British journal of psychiatry : the journal of mental science. 2023;222(4):167–174. https://doi.org/10.1192/bjp.2022.194

Author

Erlangsen, Annette ; Qin, Ping ; Madsen, Trine ; Hawton, Keith ; Osler, Merete ; Hjorthøj, Carsten ; Benros, Michael E ; Ethelberg, Steen ; Mølbak, Kåre ; Laursen, Thomas Munk ; Nordentoft, Merete ; Nilsson, Sandra Feodor. / Association between SARS-CoV-2 infection and self-harm : Danish nationwide register-based cohort study. I: The British journal of psychiatry : the journal of mental science. 2023 ; Bind 222, Nr. 4. s. 167–174.

Bibtex

@article{174a5b4c8e67445582cb64d407c9fc94,
title = "Association between SARS-CoV-2 infection and self-harm: Danish nationwide register-based cohort study",
abstract = "BACKGROUND: Case studies have linked SARS-CoV-2 infection to suicidal behaviour. However, conclusive evidence is lacking.AIMS: To examine whether a history of SARS-CoV-2 infection or SARS-CoV-2-related hospital admission was associated with self-harm in the general population and in high-risk groups.METHOD: A cohort design was applied to nationwide data on all people aged ≥15 years and living in Denmark between 27 February 2020 and 15 October 2021. Exposure was identified as having had a positive SARS-CoV-2 PCR test, and further assessed as SARS-CoV-2-related hospital admission. Rates of probable self-harm were examined using adjusted incidence rate ratios (aIRRs). The following subgroups were identified: (a) lower educational level, (b) chronic medical conditions, (c) disability pension, (d) mental disorders, (e) substance use disorders, and history of (f) homelessness and (g) imprisonment.RESULTS: Among 4 412 248 included individuals, 260 663 (5.9%) had tested positive for SARS-CoV-2. Out of 5453 individuals presenting with self-harm, 131 (2.4%) had been infected. Individuals with a history of a positive SARS-CoV-2 test result had an aIRR for self-harm of 0.86 (95% CI 0.72-1.03) compared with those without. High rates were found after a SARS-CoV-2-related hospital admission (aIRR = 7.68; 95% CI 5.61-10.51) or a non-SARS-CoV-2-related admission (aIRR = 10.27; 95% CI 9.65-10.93) versus non-infected and not admitted. In sensitivity analyses with a more restrictive definition of self-harm, a positive PCR test was associated with lower rates of self-harm.CONCLUSIONS: Individuals with a PCR-confirmed SARS-CoV-2 infection did not have higher rates of self-harm than those without. Hospital admission in general, rather than being SARS-CoV-2 positive. seemed to be linked to elevated rates of self-harm.",
author = "Annette Erlangsen and Ping Qin and Trine Madsen and Keith Hawton and Merete Osler and Carsten Hjorth{\o}j and Benros, {Michael E} and Steen Ethelberg and K{\aa}re M{\o}lbak and Laursen, {Thomas Munk} and Merete Nordentoft and Nilsson, {Sandra Feodor}",
year = "2023",
doi = "10.1192/bjp.2022.194",
language = "English",
volume = "222",
pages = "167–174",
journal = "The Journal of mental science",
issn = "0960-5371",
publisher = "Royal College of Psychiatrists",
number = "4",

}

RIS

TY - JOUR

T1 - Association between SARS-CoV-2 infection and self-harm

T2 - Danish nationwide register-based cohort study

AU - Erlangsen, Annette

AU - Qin, Ping

AU - Madsen, Trine

AU - Hawton, Keith

AU - Osler, Merete

AU - Hjorthøj, Carsten

AU - Benros, Michael E

AU - Ethelberg, Steen

AU - Mølbak, Kåre

AU - Laursen, Thomas Munk

AU - Nordentoft, Merete

AU - Nilsson, Sandra Feodor

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Case studies have linked SARS-CoV-2 infection to suicidal behaviour. However, conclusive evidence is lacking.AIMS: To examine whether a history of SARS-CoV-2 infection or SARS-CoV-2-related hospital admission was associated with self-harm in the general population and in high-risk groups.METHOD: A cohort design was applied to nationwide data on all people aged ≥15 years and living in Denmark between 27 February 2020 and 15 October 2021. Exposure was identified as having had a positive SARS-CoV-2 PCR test, and further assessed as SARS-CoV-2-related hospital admission. Rates of probable self-harm were examined using adjusted incidence rate ratios (aIRRs). The following subgroups were identified: (a) lower educational level, (b) chronic medical conditions, (c) disability pension, (d) mental disorders, (e) substance use disorders, and history of (f) homelessness and (g) imprisonment.RESULTS: Among 4 412 248 included individuals, 260 663 (5.9%) had tested positive for SARS-CoV-2. Out of 5453 individuals presenting with self-harm, 131 (2.4%) had been infected. Individuals with a history of a positive SARS-CoV-2 test result had an aIRR for self-harm of 0.86 (95% CI 0.72-1.03) compared with those without. High rates were found after a SARS-CoV-2-related hospital admission (aIRR = 7.68; 95% CI 5.61-10.51) or a non-SARS-CoV-2-related admission (aIRR = 10.27; 95% CI 9.65-10.93) versus non-infected and not admitted. In sensitivity analyses with a more restrictive definition of self-harm, a positive PCR test was associated with lower rates of self-harm.CONCLUSIONS: Individuals with a PCR-confirmed SARS-CoV-2 infection did not have higher rates of self-harm than those without. Hospital admission in general, rather than being SARS-CoV-2 positive. seemed to be linked to elevated rates of self-harm.

AB - BACKGROUND: Case studies have linked SARS-CoV-2 infection to suicidal behaviour. However, conclusive evidence is lacking.AIMS: To examine whether a history of SARS-CoV-2 infection or SARS-CoV-2-related hospital admission was associated with self-harm in the general population and in high-risk groups.METHOD: A cohort design was applied to nationwide data on all people aged ≥15 years and living in Denmark between 27 February 2020 and 15 October 2021. Exposure was identified as having had a positive SARS-CoV-2 PCR test, and further assessed as SARS-CoV-2-related hospital admission. Rates of probable self-harm were examined using adjusted incidence rate ratios (aIRRs). The following subgroups were identified: (a) lower educational level, (b) chronic medical conditions, (c) disability pension, (d) mental disorders, (e) substance use disorders, and history of (f) homelessness and (g) imprisonment.RESULTS: Among 4 412 248 included individuals, 260 663 (5.9%) had tested positive for SARS-CoV-2. Out of 5453 individuals presenting with self-harm, 131 (2.4%) had been infected. Individuals with a history of a positive SARS-CoV-2 test result had an aIRR for self-harm of 0.86 (95% CI 0.72-1.03) compared with those without. High rates were found after a SARS-CoV-2-related hospital admission (aIRR = 7.68; 95% CI 5.61-10.51) or a non-SARS-CoV-2-related admission (aIRR = 10.27; 95% CI 9.65-10.93) versus non-infected and not admitted. In sensitivity analyses with a more restrictive definition of self-harm, a positive PCR test was associated with lower rates of self-harm.CONCLUSIONS: Individuals with a PCR-confirmed SARS-CoV-2 infection did not have higher rates of self-harm than those without. Hospital admission in general, rather than being SARS-CoV-2 positive. seemed to be linked to elevated rates of self-harm.

U2 - 10.1192/bjp.2022.194

DO - 10.1192/bjp.2022.194

M3 - Journal article

C2 - 36636817

VL - 222

SP - 167

EP - 174

JO - The Journal of mental science

JF - The Journal of mental science

SN - 0960-5371

IS - 4

ER -

ID: 334788439