Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination

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Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. / Timmermann, Clara Amalie Gade; Budtz-Jørgensen, Esben; Jensen, Tina Kold; Osuna, Christa Elyse; Petersen, Maria Skaalum; Steuerwald, Ulrike; Nielsen, Flemming; Poulsen, Lars K.; Weihe, Pál; Grandjean, Philippe.

I: Journal of Immunotoxicology, Bind 14, Nr. 1, 2017, s. 39-49.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Timmermann, CAG, Budtz-Jørgensen, E, Jensen, TK, Osuna, CE, Petersen, MS, Steuerwald, U, Nielsen, F, Poulsen, LK, Weihe, P & Grandjean, P 2017, 'Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination', Journal of Immunotoxicology, bind 14, nr. 1, s. 39-49. https://doi.org/10.1080/1547691X.2016.1254306

APA

Timmermann, C. A. G., Budtz-Jørgensen, E., Jensen, T. K., Osuna, C. E., Petersen, M. S., Steuerwald, U., ... Grandjean, P. (2017). Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. Journal of Immunotoxicology, 14(1), 39-49. https://doi.org/10.1080/1547691X.2016.1254306

Vancouver

Timmermann CAG, Budtz-Jørgensen E, Jensen TK, Osuna CE, Petersen MS, Steuerwald U o.a. Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. Journal of Immunotoxicology. 2017;14(1):39-49. https://doi.org/10.1080/1547691X.2016.1254306

Author

Timmermann, Clara Amalie Gade ; Budtz-Jørgensen, Esben ; Jensen, Tina Kold ; Osuna, Christa Elyse ; Petersen, Maria Skaalum ; Steuerwald, Ulrike ; Nielsen, Flemming ; Poulsen, Lars K. ; Weihe, Pál ; Grandjean, Philippe. / Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. I: Journal of Immunotoxicology. 2017 ; Bind 14, Nr. 1. s. 39-49.

Bibtex

@article{4f70f821919e4500a6bc124dfdb7a202,
title = "Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination",
abstract = "Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined. A total of 559 children were included in the analyses. Interactions with MMR vaccination were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS exposure was not associated with childhood asthma or allergic diseases regardless of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated with increased risk of asthma among a small subgroup of MMR-unvaccinated children but not among MMR-vaccinated children. While PFAS exposure may impact immune system functions, this study suggests that MMR vaccination might be a potential effect-modifier.",
author = "Timmermann, {Clara Amalie Gade} and Esben Budtz-J{\o}rgensen and Jensen, {Tina Kold} and Osuna, {Christa Elyse} and Petersen, {Maria Skaalum} and Ulrike Steuerwald and Flemming Nielsen and Poulsen, {Lars K.} and P{\'a}l Weihe and Philippe Grandjean",
year = "2017",
doi = "10.1080/1547691X.2016.1254306",
language = "English",
volume = "14",
pages = "39--49",
journal = "Journal of Immunotoxicology",
issn = "1547-691X",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination

AU - Timmermann, Clara Amalie Gade

AU - Budtz-Jørgensen, Esben

AU - Jensen, Tina Kold

AU - Osuna, Christa Elyse

AU - Petersen, Maria Skaalum

AU - Steuerwald, Ulrike

AU - Nielsen, Flemming

AU - Poulsen, Lars K.

AU - Weihe, Pál

AU - Grandjean, Philippe

PY - 2017

Y1 - 2017

N2 - Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined. A total of 559 children were included in the analyses. Interactions with MMR vaccination were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS exposure was not associated with childhood asthma or allergic diseases regardless of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated with increased risk of asthma among a small subgroup of MMR-unvaccinated children but not among MMR-vaccinated children. While PFAS exposure may impact immune system functions, this study suggests that MMR vaccination might be a potential effect-modifier.

AB - Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined. A total of 559 children were included in the analyses. Interactions with MMR vaccination were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS exposure was not associated with childhood asthma or allergic diseases regardless of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated with increased risk of asthma among a small subgroup of MMR-unvaccinated children but not among MMR-vaccinated children. While PFAS exposure may impact immune system functions, this study suggests that MMR vaccination might be a potential effect-modifier.

U2 - 10.1080/1547691X.2016.1254306

DO - 10.1080/1547691X.2016.1254306

M3 - Journal article

C2 - 28091126

VL - 14

SP - 39

EP - 49

JO - Journal of Immunotoxicology

JF - Journal of Immunotoxicology

SN - 1547-691X

IS - 1

ER -

ID: 172150174