TY - JOUR

T1 - Anti-inflammatory treatment and risk of depression in 91,842 patients with acute coronary syndrome and 91,860 individuals without acute coronary syndrome in Denmark

AU - Wium-Andersen, Ida Kim

AU - Wium-Andersen, Marie Kim

AU - Jørgensen, Martin Balslev

AU - Osler, Merete

PY - 2017

Y1 - 2017

N2 - Background We examined if treatment with acetylsalicylic acid (ASA), non-steroid anti-inflammatory drugs (NSAID), or statins after acute coronary syndrome (ACS) are associated with decreased risk of depression. Method This register-based cohort study included all individuals with a first-time hospital admissions with an ACS diagnosis registered between January 2001 to December 2009 (N = 91,842) and a comparable reference population without ACS (N = 91,860). Information of ASA, NSAID, and statin use were retrieved from a national prescription register. The study population was followed for hospitalization with depression or receiving prescription of antidepressant medication for up to one year after ACS or study entry (early depression) or one to twelve years after ACS or study entry (late depression). Results ASA use after ACS was associated with decreased risk of early depression with hazard ratios (HR) of 0.89 (95% confidence interval 0.85–0.93) but not with late depression 0.96 (0.90–1.01). The corresponding HRs for statin were 0.90 (0.86–0.94) and 0.86 (0.82–0.90). In the non-ACS population, statin use was not associated with neither early nor late depression (HRs 1.04 (0.96–1.12) and 1.00 (0.95–1.06)), while ASA was associated with increased risk of late (HR 1.09 (1.04–1.14)) but not early depression (HR 1.03 (0.97–1.09)). In both populations, NSAID use was associated with increased risk of late but not early depression. Conclusion Use of ASA or statins were associated with decreased risk of depression in ACS patients but not in individuals without ACS, while use of NSAID was associated with increased risk of late depression in both populations.

AB - Background We examined if treatment with acetylsalicylic acid (ASA), non-steroid anti-inflammatory drugs (NSAID), or statins after acute coronary syndrome (ACS) are associated with decreased risk of depression. Method This register-based cohort study included all individuals with a first-time hospital admissions with an ACS diagnosis registered between January 2001 to December 2009 (N = 91,842) and a comparable reference population without ACS (N = 91,860). Information of ASA, NSAID, and statin use were retrieved from a national prescription register. The study population was followed for hospitalization with depression or receiving prescription of antidepressant medication for up to one year after ACS or study entry (early depression) or one to twelve years after ACS or study entry (late depression). Results ASA use after ACS was associated with decreased risk of early depression with hazard ratios (HR) of 0.89 (95% confidence interval 0.85–0.93) but not with late depression 0.96 (0.90–1.01). The corresponding HRs for statin were 0.90 (0.86–0.94) and 0.86 (0.82–0.90). In the non-ACS population, statin use was not associated with neither early nor late depression (HRs 1.04 (0.96–1.12) and 1.00 (0.95–1.06)), while ASA was associated with increased risk of late (HR 1.09 (1.04–1.14)) but not early depression (HR 1.03 (0.97–1.09)). In both populations, NSAID use was associated with increased risk of late but not early depression. Conclusion Use of ASA or statins were associated with decreased risk of depression in ACS patients but not in individuals without ACS, while use of NSAID was associated with increased risk of late depression in both populations.

KW - Acetylsalicylic acid

KW - Acute coronary syndrome

KW - Anti-inflammatory treatment

KW - Depression

KW - NSAID

KW - Statin

U2 - 10.1016/j.ijcard.2017.05.105

DO - 10.1016/j.ijcard.2017.05.105

M3 - Journal article

C2 - 28867006

AN - SCOPUS:85028548889

VL - 246

SP - 1

EP - 6

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -