Alcohol-related morbidity and mortality within siblings

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Standard

Alcohol-related morbidity and mortality within siblings. / Søndergaard, Grethe; Osler, Merete; Andersen, Anne-Marie Nybo; Andersen, Per Kragh; Dalton, Susanne Oksbjerg; Mortensen, Laust H.

I: Addiction, Bind 110, Nr. 3, 03.2015, s. 451-460.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Søndergaard, G, Osler, M, Andersen, A-MN, Andersen, PK, Dalton, SO & Mortensen, LH 2015, 'Alcohol-related morbidity and mortality within siblings', Addiction, bind 110, nr. 3, s. 451-460. https://doi.org/10.1111/add.12823

APA

Søndergaard, G., Osler, M., Andersen, A-M. N., Andersen, P. K., Dalton, S. O., & Mortensen, L. H. (2015). Alcohol-related morbidity and mortality within siblings. Addiction, 110(3), 451-460. https://doi.org/10.1111/add.12823

Vancouver

Søndergaard G, Osler M, Andersen A-MN, Andersen PK, Dalton SO, Mortensen LH. Alcohol-related morbidity and mortality within siblings. Addiction. 2015 mar;110(3):451-460. https://doi.org/10.1111/add.12823

Author

Søndergaard, Grethe ; Osler, Merete ; Andersen, Anne-Marie Nybo ; Andersen, Per Kragh ; Dalton, Susanne Oksbjerg ; Mortensen, Laust H. / Alcohol-related morbidity and mortality within siblings. I: Addiction. 2015 ; Bind 110, Nr. 3. s. 451-460.

Bibtex

@article{a57e9a726b0e4897942feae7db699f0a,
title = "Alcohol-related morbidity and mortality within siblings",
abstract = "AIMS: To estimate the association between educational status and alcohol-related somatic and non-somatic morbidity and mortality among full siblings in comparison with non-related individuals.DESIGN: Cohort study.SETTING: Denmark.PARTICIPANTS: Approximately 1.4 million full siblings born in Denmark between 1950 and 1979 were followed from age 28-58 years or censoring due to alcohol-related hospitalization and mortality.MEASUREMENTS: Cox regression analyses were used to estimate associations of educational status with alcohol-related outcomes. Results from cohort analyses based on non-related individuals and inter-sibling analyses were compared.FINDINGS: A lower educational status was associated with a higher rate of alcohol-related outcomes, especially among the youngest (aged 28-37 years) and individuals born 1970-79. Compared with the cohort analyses, the associations attenuated slightly in the inter-sibling analysis. For example, in the cohort analysis, females with a basic school education born 1970-79 had an increased rate of alcohol-related non-somatic morbidity and mortality [hazard rate ratio (HR) = 4.05, 95{\%} confidence interval (CI) = 3.27-5.02] compared to those with a vocational education. In the inter-sibling analysis, the HR attenuated (HR = 2.66, 95{\%} CI = 1.95-3.63). For alcohol-related somatic outcomes the corresponding figures were HR = 3.47 (95{\%} CI = 2.63-4.58) and HR = 3.36 (95{\%} CI = 2.10-5.38), respectively. In general, the associations were stronger among females than males (aged 28-37) in the analyses of alcohol-related non-somatic outcomes. Health conditions earlier in life explained only a minor part of the associations.CONCLUSIONS: The association between educational status and alcohol-related somatic and non-somatic morbidity and mortality is only driven by familial factors to a small degree.",
author = "Grethe S{\o}ndergaard and Merete Osler and Andersen, {Anne-Marie Nybo} and Andersen, {Per Kragh} and Dalton, {Susanne Oksbjerg} and Mortensen, {Laust H}",
note = "{\circledC} 2014 Society for the Study of Addiction.",
year = "2015",
month = "3",
doi = "10.1111/add.12823",
language = "English",
volume = "110",
pages = "451--460",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Alcohol-related morbidity and mortality within siblings

AU - Søndergaard, Grethe

AU - Osler, Merete

AU - Andersen, Anne-Marie Nybo

AU - Andersen, Per Kragh

AU - Dalton, Susanne Oksbjerg

AU - Mortensen, Laust H

N1 - © 2014 Society for the Study of Addiction.

PY - 2015/3

Y1 - 2015/3

N2 - AIMS: To estimate the association between educational status and alcohol-related somatic and non-somatic morbidity and mortality among full siblings in comparison with non-related individuals.DESIGN: Cohort study.SETTING: Denmark.PARTICIPANTS: Approximately 1.4 million full siblings born in Denmark between 1950 and 1979 were followed from age 28-58 years or censoring due to alcohol-related hospitalization and mortality.MEASUREMENTS: Cox regression analyses were used to estimate associations of educational status with alcohol-related outcomes. Results from cohort analyses based on non-related individuals and inter-sibling analyses were compared.FINDINGS: A lower educational status was associated with a higher rate of alcohol-related outcomes, especially among the youngest (aged 28-37 years) and individuals born 1970-79. Compared with the cohort analyses, the associations attenuated slightly in the inter-sibling analysis. For example, in the cohort analysis, females with a basic school education born 1970-79 had an increased rate of alcohol-related non-somatic morbidity and mortality [hazard rate ratio (HR) = 4.05, 95% confidence interval (CI) = 3.27-5.02] compared to those with a vocational education. In the inter-sibling analysis, the HR attenuated (HR = 2.66, 95% CI = 1.95-3.63). For alcohol-related somatic outcomes the corresponding figures were HR = 3.47 (95% CI = 2.63-4.58) and HR = 3.36 (95% CI = 2.10-5.38), respectively. In general, the associations were stronger among females than males (aged 28-37) in the analyses of alcohol-related non-somatic outcomes. Health conditions earlier in life explained only a minor part of the associations.CONCLUSIONS: The association between educational status and alcohol-related somatic and non-somatic morbidity and mortality is only driven by familial factors to a small degree.

AB - AIMS: To estimate the association between educational status and alcohol-related somatic and non-somatic morbidity and mortality among full siblings in comparison with non-related individuals.DESIGN: Cohort study.SETTING: Denmark.PARTICIPANTS: Approximately 1.4 million full siblings born in Denmark between 1950 and 1979 were followed from age 28-58 years or censoring due to alcohol-related hospitalization and mortality.MEASUREMENTS: Cox regression analyses were used to estimate associations of educational status with alcohol-related outcomes. Results from cohort analyses based on non-related individuals and inter-sibling analyses were compared.FINDINGS: A lower educational status was associated with a higher rate of alcohol-related outcomes, especially among the youngest (aged 28-37 years) and individuals born 1970-79. Compared with the cohort analyses, the associations attenuated slightly in the inter-sibling analysis. For example, in the cohort analysis, females with a basic school education born 1970-79 had an increased rate of alcohol-related non-somatic morbidity and mortality [hazard rate ratio (HR) = 4.05, 95% confidence interval (CI) = 3.27-5.02] compared to those with a vocational education. In the inter-sibling analysis, the HR attenuated (HR = 2.66, 95% CI = 1.95-3.63). For alcohol-related somatic outcomes the corresponding figures were HR = 3.47 (95% CI = 2.63-4.58) and HR = 3.36 (95% CI = 2.10-5.38), respectively. In general, the associations were stronger among females than males (aged 28-37) in the analyses of alcohol-related non-somatic outcomes. Health conditions earlier in life explained only a minor part of the associations.CONCLUSIONS: The association between educational status and alcohol-related somatic and non-somatic morbidity and mortality is only driven by familial factors to a small degree.

U2 - 10.1111/add.12823

DO - 10.1111/add.12823

M3 - Journal article

VL - 110

SP - 451

EP - 460

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 3

ER -

ID: 135436694