Age-related macular degeneration: A two-level model hypothesis

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Age-related macular degeneration : A two-level model hypothesis. / Rozing, Maarten Pieter; Durhuus, Jon Ambæk; Krogh Nielsen, Marie; Subhi, Yousif; Kirkwood, Thomas Burton Loram; Westendorp, Rudi GJ; Sørensen, Torben Lykke.

I: Progress in Retinal and Eye Research, Bind 76, 100825, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Rozing, MP, Durhuus, JA, Krogh Nielsen, M, Subhi, Y, Kirkwood, TBL, Westendorp, RGJ & Sørensen, TL 2020, 'Age-related macular degeneration: A two-level model hypothesis', Progress in Retinal and Eye Research, bind 76, 100825. https://doi.org/10.1016/j.preteyeres.2019.100825

APA

Rozing, M. P., Durhuus, J. A., Krogh Nielsen, M., Subhi, Y., Kirkwood, T. B. L., Westendorp, R. GJ., & Sørensen, T. L. (2020). Age-related macular degeneration: A two-level model hypothesis. Progress in Retinal and Eye Research, 76, [100825]. https://doi.org/10.1016/j.preteyeres.2019.100825

Vancouver

Rozing MP, Durhuus JA, Krogh Nielsen M, Subhi Y, Kirkwood TBL, Westendorp RGJ o.a. Age-related macular degeneration: A two-level model hypothesis. Progress in Retinal and Eye Research. 2020;76. 100825. https://doi.org/10.1016/j.preteyeres.2019.100825

Author

Rozing, Maarten Pieter ; Durhuus, Jon Ambæk ; Krogh Nielsen, Marie ; Subhi, Yousif ; Kirkwood, Thomas Burton Loram ; Westendorp, Rudi GJ ; Sørensen, Torben Lykke. / Age-related macular degeneration : A two-level model hypothesis. I: Progress in Retinal and Eye Research. 2020 ; Bind 76.

Bibtex

@article{f4d63d2a49af4529b22c42ca4fba9127,
title = "Age-related macular degeneration: A two-level model hypothesis",
abstract = "Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pathophysiology of AMD. Ageing is both multicausal and variable, so that differences between individuals in biological ageing processes are the focus of a growing number of pathophysiological studies seeking to explain how ageing contributes to chronic, age-related conditions. The aim of this review is to integrate the available knowledge on the pathophysiology of AMD within the framework of the biology of ageing. One highly significant feature of biological ageing is systemic inflammation, which arises as a second-level response to a first level of molecular damage involving oxidative stress, mutations etc. Combining these insights, the various co-existing pathophysiological explanations in AMD arrange themselves according to a two-level hypothesis. Accordingly, we describe how AMD can be considered the consequence of age-related random accumulation of molecular damage at the ocular level and the subsequent systemic inflammatory host response thereof. We summarize evidence and provide original data to enlighten where evidence is lacking. Finally, we discuss how this two-level hypothesis provides a foundation for thoughts and future studies in prevention, prognosis, and intervention.",
author = "Rozing, {Maarten Pieter} and Durhuus, {Jon Amb{\ae}k} and {Krogh Nielsen}, Marie and Yousif Subhi and Kirkwood, {Thomas Burton Loram} and Westendorp, {Rudi GJ} and S{\o}rensen, {Torben Lykke}",
year = "2020",
doi = "10.1016/j.preteyeres.2019.100825",
language = "English",
volume = "76",
journal = "Progress in Retinal and Eye Research",
issn = "1350-9462",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Age-related macular degeneration

T2 - A two-level model hypothesis

AU - Rozing, Maarten Pieter

AU - Durhuus, Jon Ambæk

AU - Krogh Nielsen, Marie

AU - Subhi, Yousif

AU - Kirkwood, Thomas Burton Loram

AU - Westendorp, Rudi GJ

AU - Sørensen, Torben Lykke

PY - 2020

Y1 - 2020

N2 - Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pathophysiology of AMD. Ageing is both multicausal and variable, so that differences between individuals in biological ageing processes are the focus of a growing number of pathophysiological studies seeking to explain how ageing contributes to chronic, age-related conditions. The aim of this review is to integrate the available knowledge on the pathophysiology of AMD within the framework of the biology of ageing. One highly significant feature of biological ageing is systemic inflammation, which arises as a second-level response to a first level of molecular damage involving oxidative stress, mutations etc. Combining these insights, the various co-existing pathophysiological explanations in AMD arrange themselves according to a two-level hypothesis. Accordingly, we describe how AMD can be considered the consequence of age-related random accumulation of molecular damage at the ocular level and the subsequent systemic inflammatory host response thereof. We summarize evidence and provide original data to enlighten where evidence is lacking. Finally, we discuss how this two-level hypothesis provides a foundation for thoughts and future studies in prevention, prognosis, and intervention.

AB - Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pathophysiology of AMD. Ageing is both multicausal and variable, so that differences between individuals in biological ageing processes are the focus of a growing number of pathophysiological studies seeking to explain how ageing contributes to chronic, age-related conditions. The aim of this review is to integrate the available knowledge on the pathophysiology of AMD within the framework of the biology of ageing. One highly significant feature of biological ageing is systemic inflammation, which arises as a second-level response to a first level of molecular damage involving oxidative stress, mutations etc. Combining these insights, the various co-existing pathophysiological explanations in AMD arrange themselves according to a two-level hypothesis. Accordingly, we describe how AMD can be considered the consequence of age-related random accumulation of molecular damage at the ocular level and the subsequent systemic inflammatory host response thereof. We summarize evidence and provide original data to enlighten where evidence is lacking. Finally, we discuss how this two-level hypothesis provides a foundation for thoughts and future studies in prevention, prognosis, and intervention.

U2 - 10.1016/j.preteyeres.2019.100825

DO - 10.1016/j.preteyeres.2019.100825

M3 - Journal article

C2 - 31899290

VL - 76

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

SN - 1350-9462

M1 - 100825

ER -

ID: 232910318