A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka: Study protocol
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka : Study protocol. / Pearson, Melissa; Konradsen, Flemming; Gunnell, David; Dawson, Andrew H; Pieris, Ravi; Weerasinghe, Manjula; Knipe, Duleeka W; Jayamanne, Shaluka; Metcalfe, Chris; Hawton, Keith; Wickramasinghe, A Rajitha; Atapattu, W; Bandara, Palitha; de Silva, Dhammika; Ranasinghe, Asanga; Mohamed, Fahim; Buckley, Nicholas A; Gawarammana, Indika; Eddleston, Michael.
I: B M C Public Health, Bind 11, 2011, s. 879.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka
T2 - Study protocol
AU - Pearson, Melissa
AU - Konradsen, Flemming
AU - Gunnell, David
AU - Dawson, Andrew H
AU - Pieris, Ravi
AU - Weerasinghe, Manjula
AU - Knipe, Duleeka W
AU - Jayamanne, Shaluka
AU - Metcalfe, Chris
AU - Hawton, Keith
AU - Wickramasinghe, A Rajitha
AU - Atapattu, W
AU - Bandara, Palitha
AU - de Silva, Dhammika
AU - Ranasinghe, Asanga
AU - Mohamed, Fahim
AU - Buckley, Nicholas A
AU - Gawarammana, Indika
AU - Eddleston, Michael
PY - 2011
Y1 - 2011
N2 - Background The WHO recognises pesticide poisoning to be the single most important means of suicide globally. Pesticide self-poisoning is a major public health and clinical problem in rural Asia, where it has led to case fatality ratios 20-30 times higher than self-poisoning in the developed world. One approach to reducing access to pesticides is for households to store pesticides in lockable "safe-storage" containers. However, before this approach can be promoted, evidence is required on its effectiveness and safety. Methods/Design A community-based cluster randomised controlled trial has been set up in 44,000 households in the North Central Province, Sri Lanka. A census is being performed, collecting baseline demographic data, socio-economic status, pesticide usage, self-harm and alcohol. Participating villages are then randomised and eligible households in the intervention arm given a lockable safe storage container for agrochemicals. The primary outcome will be incidence of pesticide self-poisoning over three years amongst individuals aged 14 years and over. 217,944 person years of follow-up are required in each arm to detect a 33% reduction in pesticide self-poisoning with 80% power at the 5% significance level. Secondary outcomes will include the incidence of all pesticide poisoning and total self-harm. Discussion This paper describes a large effectiveness study of a community intervention to reduce the burden of intentional poisoning in rural Sri Lanka. The study builds on a strong partnership between provincial health services, local and international researchers, and local communities. We discuss issues in relation to randomisation and contamination, engaging control villages, the intervention, and strategies to improve adherence. Trial Registritation The trial is registered on ClinicalTrials.gov ref: NCT1146496 (http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01146496 webcite).
AB - Background The WHO recognises pesticide poisoning to be the single most important means of suicide globally. Pesticide self-poisoning is a major public health and clinical problem in rural Asia, where it has led to case fatality ratios 20-30 times higher than self-poisoning in the developed world. One approach to reducing access to pesticides is for households to store pesticides in lockable "safe-storage" containers. However, before this approach can be promoted, evidence is required on its effectiveness and safety. Methods/Design A community-based cluster randomised controlled trial has been set up in 44,000 households in the North Central Province, Sri Lanka. A census is being performed, collecting baseline demographic data, socio-economic status, pesticide usage, self-harm and alcohol. Participating villages are then randomised and eligible households in the intervention arm given a lockable safe storage container for agrochemicals. The primary outcome will be incidence of pesticide self-poisoning over three years amongst individuals aged 14 years and over. 217,944 person years of follow-up are required in each arm to detect a 33% reduction in pesticide self-poisoning with 80% power at the 5% significance level. Secondary outcomes will include the incidence of all pesticide poisoning and total self-harm. Discussion This paper describes a large effectiveness study of a community intervention to reduce the burden of intentional poisoning in rural Sri Lanka. The study builds on a strong partnership between provincial health services, local and international researchers, and local communities. We discuss issues in relation to randomisation and contamination, engaging control villages, the intervention, and strategies to improve adherence. Trial Registritation The trial is registered on ClinicalTrials.gov ref: NCT1146496 (http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01146496 webcite).
KW - Cluster Analysis
KW - Housing
KW - Humans
KW - Pesticides
KW - Poisoning
KW - Product Packaging
KW - Rural Population
KW - Sri Lanka
KW - Suicide
U2 - 10.1186/1471-2458-11-879
DO - 10.1186/1471-2458-11-879
M3 - Journal article
C2 - 22104027
VL - 11
SP - 879
JO - BMC Public Health
JF - BMC Public Health
SN - 1471-2458
ER -
ID: 40130896