Jiri Lukas

Jiri Lukas

Administrerende Direktør

Medlem af:

    Primære forskningsområder

    Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.

    Aktuel forskning

    Recent discoveries from Jiri’s lab include:

    • Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
    • Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
    • The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome

    Udvalgte publikationer

    1. Udgivet

      Stabilization of chromatin topology safeguards genome integrity

      Ochs, Fena, Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, I: Nature. 574, 7779, s. 571-574 4 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    2. Udgivet

      Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

      Toledo, L., Neelsen, K. J. & Lukas, Jiri, 15 jun. 2017, I: Molecular Cell. 66, 6, s. 735-749 15 s.

      Publikation: Bidrag til tidsskriftReviewfagfællebedømt

    3. Udgivet

      Redox-sensitive alteration of replisome architecture safeguards genome integrity

      Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 nov. 2017, I: Science. 358, 6364, s. 797-802 6 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    4. Udgivet

      ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

      Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 nov. 2013, I: Cell. 155, 5, s. 1088-1103 16 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    5. Udgivet

      TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

      Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 aug. 2012, I: Cell. 150, 4, s. 697-709 13 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    6. Udgivet

      53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

      Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 mar. 2011, I: Nature Cell Biology. 13, 3, s. 243-53 11 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    7. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

      Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, I: Cell. 136, 3, s. 435-46 11 s.

      Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

    ID: 37762642